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10.1128/AAC.01652-20 http://scihub22266oqcxt.onion/10.1128/AAC.01652-20 33122172!7927863!33122172     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antimicrob+Agents+Chemother 2020 ; 65 (1): ä Nephropedia Template TP {{tp|p=33122172|t=2020. Repurposing Nucleoside Analogs for Human Coronaviruses |pdf=|usr=}}{{33122172}} gab.com Text Repurposing Nucleoside Analogs for Human Coronaviruses JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=33122172 #FOAvip Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed certain nucleoside analogs to be active against CoV-2 and thus needed confirmation. Here, we evaluated a panel of compounds and identified novel nucleoside analogs with antiviral activity against CoV-2 and HCoV-OC43 while ruling out others. Of significance, sofosbuvir demonstrated no antiviral effect against CoV-2, and its triphosphate did not inhibit CoV-2 RNA polymerase. Twit Text FOAVip Repurposing Nucleoside Analogs for Human Coronaviruses ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=33122172 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33122172 #FOAvip English Wikipedia <ref>{{Cite pmid|33122172}}</ref> Repurposing Nucleoside Analogs for Human Coronaviruses #MMPMID33122172 Zandi K; Amblard F; Musall K; Downs-Bowen J; Kleinbard R; Oo A; Cao D; Liang B; Russell OO; McBrayer T; Bassit L; Kim B; Schinazi RF Antimicrob Agents Chemother 2020[Dec]; 65 (1): ä PMID33122172show ga Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed certain nucleoside analogs to be active against CoV-2 and thus needed confirmation. Here, we evaluated a panel of compounds and identified novel nucleoside analogs with antiviral activity against CoV-2 and HCoV-OC43 while ruling out others. Of significance, sofosbuvir demonstrated no antiviral effect against CoV-2, and its triphosphate did not inhibit CoV-2 RNA polymerase. |Animals[MESH] |Antiviral Agents/chemistry/*pharmacology/toxicity[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Coronavirus OC43, Human/drug effects[MESH] |Drug Evaluation, Preclinical[MESH] |Drug Repositioning/*methods[MESH] |Humans[MESH] |Nucleosides/chemistry/*pharmacology/toxicity[MESH] |Propanolamines/pharmacology[MESH] |SARS-CoV-2/*drug effects[MESH] |Sofosbuvir/pharmacology[MESH]Repurposing Nucleoside Analogs for Human Coronaviruses (epmc).pdf DeepDyve Pubget Overpricing