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10.1016/j.cbi.2020.109298

http://scihub22266oqcxt.onion/10.1016/j.cbi.2020.109298
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suck abstract from ncbi

pmid33121920      Chem+Biol+Interact 2020 ; 332 (?): 109298
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  • Race to arsenal COVID-19 therapeutics: Current alarming status and future directions #MMPMID33121920
  • Dubey AK; Singh A; Prakash S; Kumar M; Singh AK
  • Chem Biol Interact 2020[Dec]; 332 (?): 109298 PMID33121920show ga
  • The on-going pandemic of COVID-19 wreaked by a viral infection of SARS-CoV-2, has generated a catastrophic plight across the globe. Interestingly, one of the hallmarks of COVID-19 is the so-called 'cytokine storm' due to attack of SARS-Cov-2 in the lungs. Considering, mesenchymal stem cells (MSCs) therapy could contribute against SARS-CoV-2 viruses attack because of their immune modulatory and anti-inflammatory ability linked to their stemness, to the arsenal of treatments for COVID-19. Another novel therapeutic strategies include the blockade of rampant generation of pro-inflammatory mediators like acute respiratory distress syndrome (ARDS), degradation of viral protein capsids by PROTACs, composed of Ubiquitin-proteasome framework, and ubiquitination-independent pathway directing the SARS-CoV-2 nucleocapsid protein (nCoV N) and proteasome activator (PA28gamma), etc. This review is consequently an endeavour to highlight the several aspects of COVID-19 with incorporation of important treatment strategies discovered to date and putting the real effort on the future directions to put them into the perspective.
  • |*COVID-19 Drug Treatment[MESH]
  • |Animals[MESH]
  • |COVID-19/epidemiology/etiology/therapy[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]


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