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10.1016/j.jacc.2020.08.070

http://scihub22266oqcxt.onion/10.1016/j.jacc.2020.08.070
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33121712!7588178!33121712
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suck abstract from ncbi


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pmid33121712      J+Am+Coll+Cardiol 2020 ; 76 (18): 2060-2072
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  • Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19 #MMPMID33121712
  • Piazza G; Campia U; Hurwitz S; Snyder JE; Rizzo SM; Pfeferman MB; Morrison RB; Leiva O; Fanikos J; Nauffal V; Almarzooq Z; Goldhaber SZ
  • J Am Coll Cardiol 2020[Nov]; 76 (18): 2060-2072 PMID33121712show ga
  • BACKGROUND: Cardiovascular complications, including myocardial infarction, ischemic stroke, and pulmonary embolism, represent an important source of adverse outcomes in coronavirus disease-2019 (COVID-19). OBJECTIVES: To assess the frequency of arterial and venous thromboembolic disease, risk factors, prevention and management patterns, and outcomes in patients with COVID-19, the authors designed a multicenter, observational cohort study. METHODS: We analyzed a retrospective cohort of 1,114 patients with COVID-19 diagnosed through our Mass General Brigham integrated health network. The total cohort was analyzed by site of care: intensive care (n = 170); hospitalized nonintensive care (n = 229); and outpatient (n = 715). The primary study outcome was a composite of adjudicated major arterial or venous thromboembolism. RESULTS: Patients with COVID-19 were 22.3% Hispanic/Latinx and 44.2% non-White. Cardiovascular risk factors of hypertension (35.8%), hyperlipidemia (28.6%), and diabetes (18.0%) were common. Prophylactic anticoagulation was prescribed in 89.4% of patients with COVID-19 in the intensive care cohort and 84.7% of those in the hospitalized nonintensive care setting. Frequencies of major arterial or venous thromboembolism, major cardiovascular adverse events, and symptomatic venous thromboembolism were highest in the intensive care cohort (35.3%, 45.9%, and 27.0 %, respectively) followed by the hospitalized nonintensive care cohort (2.6%, 6.1%, and 2.2%, respectively) and the outpatient cohort (0% for all). CONCLUSIONS: Major arterial or venous thromboembolism, major adverse cardiovascular events, and symptomatic venous thromboembolism occurred with high frequency in patients with COVID-19, especially in the intensive care setting, despite a high utilization rate of thromboprophylaxis.
  • |*Registries[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Anticoagulants/*therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/mortality[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Intensive Care Units/statistics & numerical data[MESH]
  • |Male[MESH]
  • |Massachusetts/epidemiology[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/mortality[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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