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10.1080/14786419.2020.1839452 http://scihub22266oqcxt.onion/10.1080/14786419.2020.1839452 33121282!ä!33121282 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33121282&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33121282.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Prod+Res 2022 ; 36 (4): 994-998 Nephropedia Template TP {{tp|p=33121282|t=2022. Potential of Ficus microcarpa metabolites against SARS-CoV-2 main protease supported by docking studies |pdf=|usr=}}{{33121282}} gab.com Text Potential of Ficus microcarpa metabolites against SARS-CoV-2 main protease supported by docking studies JO: Nat Prod Res http://www.kidney.de/pget.php?&tw=1&pmid=33121282 #FOAvip COVID 19; an infectious disease; firstly identified in December 2019 in Wuhan, China and has since spread globally, resulting in an ongoing pandemic. Searching for protease inhibitors is a challenging task in controlling COVID 19. Genus Ficus is known to be a rich source of phenolic compounds. Metabolic profiling of leaves methanolic extract of Ficus microcarpa (Moraceae) revealed nine compounds (1-9) mainly phenolics. Docking studies concerning these compounds against SARS-CoV-2 main protease showed that quercetin 3,7-O-alpha-L-dirhamnoside (1) and rutin (3) possessed significant binding stability at the N3 binding site in different activity degrees, which is comparable with COVID-19 main protease inhibitor, darunavir. Our study suggests that compounds quercetin 3,7-O-alpha-L-dirhamnoside and rutin might be potential candidates for the development of therapies against SARS-CoV-2. Twit Text FOAVip Potential of Ficus microcarpa metabolites against SARS-CoV-2 main protease supported by docking studies ????Nat Prod Res http://www.kidney.de/pget.php?&tw=1&pmid=33121282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33121282 #FOAvip English Wikipedia <ref>{{Cite pmid|33121282}}</ref> Potential of Ficus microcarpa metabolites against SARS-CoV-2 main protease supported by docking studies #MMPMID33121282 Hassan HA; Abdelmohsen UR; Aly OM; Desoukey SY; Mohamed KM; Kamel MS Nat Prod Res 2022[Feb]; 36 (4): 994-998 PMID33121282show ga COVID 19; an infectious disease; firstly identified in December 2019 in Wuhan, China and has since spread globally, resulting in an ongoing pandemic. Searching for protease inhibitors is a challenging task in controlling COVID 19. Genus Ficus is known to be a rich source of phenolic compounds. Metabolic profiling of leaves methanolic extract of Ficus microcarpa (Moraceae) revealed nine compounds (1-9) mainly phenolics. Docking studies concerning these compounds against SARS-CoV-2 main protease showed that quercetin 3,7-O-alpha-L-dirhamnoside (1) and rutin (3) possessed significant binding stability at the N3 binding site in different activity degrees, which is comparable with COVID-19 main protease inhibitor, darunavir. Our study suggests that compounds quercetin 3,7-O-alpha-L-dirhamnoside and rutin might be potential candidates for the development of therapies against SARS-CoV-2. |*Antiviral Agents/chemistry/pharmacology[MESH] |*COVID-19 Drug Treatment[MESH] |*Ficus/chemistry[MESH] |*Plant Extracts/chemistry/pharmacology[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH]Potential of Ficus microcarpa metabolites against SARS-CoV-2 main prot(epmc).pdf DeepDyve Pubget Overpricing