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10.3390/ijms21218001

http://scihub22266oqcxt.onion/10.3390/ijms21218001
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33121190!7663145!33121190
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suck abstract from ncbi


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pmid33121190      Int+J+Mol+Sci 2020 ; 21 (21): ä
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  • PD-1 and PD-L1 Expression on Circulating Lymphocytes as a Marker of Epstein-Barr Virus Reactivation-Associated Proliferative Glomerulonephritis #MMPMID33121190
  • Grywalska E; Smarz-Widelska I; Korona-Glowniak I; Mertowski S; Gosik K; Hymos A; Ludian J; Niedzwiedzka-Rystwej P; Rolinski J; Zaluska W
  • Int J Mol Sci 2020[Oct]; 21 (21): ä PMID33121190show ga
  • Alterations to the programmed cell death protein-1 (PD-1) pathway were previously shown to be involved in a poorer prognosis for patients with proliferative glomerulonephritis (PGN). Here, we investigated the association between several infectious agents and the expression of PD-1 and its ligand (PD-L1) on T and B lymphocytes in patients with PGN and nonproliferative glomerulonephritis (NPGN). A cohort of 45 newly-diagnosed patients (23 with PGN and 22 with NPGN) and 20 healthy volunteers was enrolled. The percentage of peripheral blood mononuclear cells expressing PD-1 and PD-L1 antigens was determined by flow cytometry. We found PD-1 and PD-L1 expression on T and B lymphocytes was higher in PGN patients than in NPGN patients and controls. We also found that reactivation of the Epstein-Barr virus (EBV) correlated with the expression of PD-1/PD-L1 antigens in patients with PGN. Further receiver operating characteristic analysis indicated that PD-1 expression could distinguish EBV-positive PGN patients from those with NPGN or healthy controls. The use of PD-1 expression as a non-invasive marker of PGN should be further investigated.
  • |Adult[MESH]
  • |Aged[MESH]
  • |B-Lymphocytes/*metabolism[MESH]
  • |B7-H1 Antigen/*metabolism[MESH]
  • |Case-Control Studies[MESH]
  • |Epstein-Barr Virus Infections/*complications/immunology[MESH]
  • |Female[MESH]
  • |Glomerulonephritis/immunology/*virology[MESH]
  • |Humans[MESH]
  • |Leukocytes, Mononuclear/metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Programmed Cell Death 1 Receptor/*metabolism[MESH]
  • |ROC Curve[MESH]
  • |T-Lymphocytes/*metabolism[MESH]
  • |Up-Regulation[MESH]


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