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10.3390/v12111216

http://scihub22266oqcxt.onion/10.3390/v12111216
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33121021!7693373!33121021
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suck abstract from ncbi


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pmid33121021      Viruses 2020 ; 12 (11): ä
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  • Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega #MMPMID33121021
  • Addie DD; Covell-Ritchie J; Jarrett O; Fosbery M
  • Viruses 2020[Oct]; 12 (11): ä PMID33121021show ga
  • This is the first report of a successful treatment of a non-effusive feline infectious peritonitis (FIP) uveitis case using an oral adenosine nucleoside analogue drug and feline interferon omega, and alpha-1 acid glycoprotein (AGP) as an indicator of recovery. A 2-year-old male neutered Norwegian Forest Cat presented with uveitis, keratic precipitates, mesenteric lymphadenopathy and weight loss. The cat was hypergammaglobulinaemic and had a non-regenerative anaemia. Feline coronavirus (FCoV) RNA was detected in a mesenteric lymph node fine-needle aspirate by a reverse-transcriptase polymerase chain reaction-non-effusive FIP was diagnosed. Prednisolone acetate eye drops were administered three times daily for 2 weeks. Oral adenosine nucleoside analogue (Mutian) treatment started. Within 50 days of Mutian treatment, the cat had gained over one kilogram in weight, his globulin level reduced from 77 to 51 g/L and his haematocrit increased from 22 to 35%; his uveitis resolved and his sight improved. Serum AGP level reduced from 3100 to 400 mug/mL (within normal limits). Symmetric dimethylarginine (SDMA) was above normal at 28 mug/dL, reducing to 14 mug/dL on the cessation of treatment; whether the SDMA increase was due to FIP lesions in the kidney or Mutian is unknown. Mutian treatment stopped and low-dose oral recombinant feline interferon omega begun-the cat's recovery continued.
  • |Adenosine/analogs & derivatives/*therapeutic use[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Arginine/analogs & derivatives/blood[MESH]
  • |Cats[MESH]
  • |Coronavirus, Feline/drug effects/isolation & purification[MESH]
  • |Feline Infectious Peritonitis/diagnosis/*drug therapy/virology[MESH]
  • |Glycoproteins/metabolism[MESH]
  • |Interferon Type I/*therapeutic use[MESH]
  • |Male[MESH]
  • |Nucleosides/*therapeutic use[MESH]


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