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10.1016/j.dsx.2020.10.021 http://scihub22266oqcxt.onion/10.1016/j.dsx.2020.10.021 33120281!7582042!33120281     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33120281&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Diabetes+Metab+Syndr 2020 ; 14 (6): 2063-2067 Nephropedia Template TP {{tp|p=33120281|t=2020. Statins and SARS-CoV-2 disease: Current concepts and possible benefits |pdf=|usr=}}{{33120281}} gab.com Text Statins and SARS-CoV-2 disease: Current concepts and possible benefits JO: Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=33120281 #FOAvip BACKGROUND AND AIMS: Inflammation-mediated tissue injury is the major mechanism involved in the pathogenesis of coronavirus disease 2019 (COVID-2019), caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Statins have well-established anti-inflammatory, anti-thrombotic and immuno-modulatory effects. They may also influence viral entry into human cells. METHODS: A literature search was done using PubMed and Google search engines to prepare a narrative review on this topic. RESULTS: Statins interact with several different signaling pathways to exert their anti-inflammatory and vasculoprotective effects. They also variably affect cholesterol content of cell membranes and interfere with certain coronavirus enzymes involved in receptor-binding. Both these actions may influence SARS-CoV-2 entry into human cells. Statins also upregulate expression of angiotensin-converting enzyme 2 receptors on cell surfaces which may promote viral entry into the cells but at the same time, may minimize tissue injury through production of angiotensin [1-7]. The net impact of these different effects on COVID-19 pathogenesis is not clear. However, the retrospective clinical studies have shown that statin use is potentially associated with lower risk of developing severe illness and mortality and a faster time to recovery in patients with COVID-19. CONCLUSIONS: Early observations suggest beneficial effect of statin use on the clinical outcomes in COVID-19. Prospective randomized studies as well as well-designed laboratory studies are required to confirm these observations and to elucidate the mechanisms of such benefits, if proven. Twit Text FOAVip Statins and SARS-CoV-2 disease: Current concepts and possible benefits ????Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=33120281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33120281 #FOAvip English Wikipedia <ref>{{Cite pmid|33120281}}</ref> Statins and SARS-CoV-2 disease: Current concepts and possible benefits #MMPMID33120281 Minz MM; Bansal M; Kasliwal RR Diabetes Metab Syndr 2020[Nov]; 14 (6): 2063-2067 PMID33120281show ga BACKGROUND AND AIMS: Inflammation-mediated tissue injury is the major mechanism involved in the pathogenesis of coronavirus disease 2019 (COVID-2019), caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Statins have well-established anti-inflammatory, anti-thrombotic and immuno-modulatory effects. They may also influence viral entry into human cells. METHODS: A literature search was done using PubMed and Google search engines to prepare a narrative review on this topic. RESULTS: Statins interact with several different signaling pathways to exert their anti-inflammatory and vasculoprotective effects. They also variably affect cholesterol content of cell membranes and interfere with certain coronavirus enzymes involved in receptor-binding. Both these actions may influence SARS-CoV-2 entry into human cells. Statins also upregulate expression of angiotensin-converting enzyme 2 receptors on cell surfaces which may promote viral entry into the cells but at the same time, may minimize tissue injury through production of angiotensin [1-7]. The net impact of these different effects on COVID-19 pathogenesis is not clear. However, the retrospective clinical studies have shown that statin use is potentially associated with lower risk of developing severe illness and mortality and a faster time to recovery in patients with COVID-19. CONCLUSIONS: Early observations suggest beneficial effect of statin use on the clinical outcomes in COVID-19. Prospective randomized studies as well as well-designed laboratory studies are required to confirm these observations and to elucidate the mechanisms of such benefits, if proven. |*COVID-19 Drug Treatment[MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use[MESH] |COVID-19/blood/epidemiology[MESH] |Humans[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/*therapeutic use[MESH] |India/epidemiology[MESH] |Inflammation Mediators/*antagonists & inhibitors/blood[MESH]Statins and SARS-CoV-2 disease: Current concepts and possible benefits(epmc).pdf DeepDyve Pubget Overpricing