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10.1371/journal.pntd.0008788 http://scihub22266oqcxt.onion/10.1371/journal.pntd.0008788 33119599!7595275!33119599     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Negl+Trop+Dis 2020 ; 14 (10): e0008788 Nephropedia Template TP {{tp|p=33119599|t=2020. A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus |pdf=|usr=}}{{33119599}} gab.com Text A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus JO: PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=33119599 #FOAvip Powassan virus (POWV) infection is a tick-borne emerging infectious disease in the United States and North America. Like Zika virus, POWV is a member of the family Flaviviridae. POWV causes severe neurological sequalae, meningitis, encephalitis, and can cause death. Although the risk of human POWV infection is low, its incidence in the U.S. in the past 16 years has increased over 300%, urging immediate attention. Despite the disease severity and its growing potential for threatening larger populations, currently there are no licensed vaccines which provide protection against POWV. We developed a novel synthetic DNA vaccine termed POWV-SEV by focusing on the conserved portions of POWV pre-membrane and envelope (prMEnv) genes. A single immunization of POWV-SEV elicited broad T and B cell immunity in mice with minimal cross-reactivity against other flaviviruses. Antibody epitope mapping demonstrated a similarity between POWV-SEV-induced immune responses and those elicited naturally in POWV-infected patients. Finally, POWV-SEV induced immunity provided protection against POWV disease in lethal challenge experiments. Twit Text FOAVip A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus ????PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=33119599 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33119599 #FOAvip English Wikipedia <ref>{{Cite pmid|33119599}}</ref> A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus #MMPMID33119599 Choi H; Kudchodkar SB; Ho M; Reuschel EL; Reynolds E; Xu Z; Bordoloi D; Ugen KE; Tebas P; Kim J; Abdel-Mohsen M; Thangamani S; Weiner DB; Muthumani K PLoS Negl Trop Dis 2020[Oct]; 14 (10): e0008788 PMID33119599show ga Powassan virus (POWV) infection is a tick-borne emerging infectious disease in the United States and North America. Like Zika virus, POWV is a member of the family Flaviviridae. POWV causes severe neurological sequalae, meningitis, encephalitis, and can cause death. Although the risk of human POWV infection is low, its incidence in the U.S. in the past 16 years has increased over 300%, urging immediate attention. Despite the disease severity and its growing potential for threatening larger populations, currently there are no licensed vaccines which provide protection against POWV. We developed a novel synthetic DNA vaccine termed POWV-SEV by focusing on the conserved portions of POWV pre-membrane and envelope (prMEnv) genes. A single immunization of POWV-SEV elicited broad T and B cell immunity in mice with minimal cross-reactivity against other flaviviruses. Antibody epitope mapping demonstrated a similarity between POWV-SEV-induced immune responses and those elicited naturally in POWV-infected patients. Finally, POWV-SEV induced immunity provided protection against POWV disease in lethal challenge experiments. |Animals[MESH] |Antibodies, Viral/immunology[MESH] |Encephalitis Viruses, Tick-Borne/genetics/*immunology[MESH] |Encephalitis, Tick-Borne/*immunology/prevention & control/virology[MESH] |Female[MESH] |Humans[MESH] |Immunity[MESH] |Immunization[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Vaccines, DNA/administration & dosage/chemical synthesis/genetics/*immunology[MESH] |Vaccines, Synthetic/administration & dosage/genetics/immunology[MESH]A novel synthetic DNA vaccine elicits protective immune responses agai(epmc).pdf DeepDyve Pubget Overpricing