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10.3389/fimmu.2020.582010 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.582010 33117392!7561365!33117392     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 582010 Nephropedia Template TP {{tp|p=33117392|t=2020. Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients |pdf=|usr=}}{{33117392}} gab.com Text Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33117392 #FOAvip Severe COVID-19 is associated with profound lymphopenia and an elevated neutrophil to lymphocyte ratio. We applied a novel dimer avoidance multiplexed polymerase chain reaction next-generation sequencing assay to analyze T (TCR) and B cell receptor (BCR) repertoires. Surprisingly, TCR repertoires were markedly diminished during the early onset of severe disease but recovered during the convalescent stage. Monitoring TCR repertoires could serve as an indicative biomarker to predict disease progression and recovery. Panoramic concurrent assessment of BCR repertoires demonstrated isotype switching and a transient but dramatic early IgA expansion. Dominant B cell clonal expansion with decreased diversity occurred following recovery from infection. Profound changes in T cell homeostasis raise critical questions about the early events in COVID-19 infection and demonstrate that immune repertoire analysis is a promising method for evaluating emergent host immunity to SARS-CoV-2 viral infection, with great implications for assessing vaccination and other immunological therapies. Twit Text FOAVip Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33117392 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33117392 #FOAvip English Wikipedia <ref>{{Cite pmid|33117392}}</ref> Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients #MMPMID33117392 Niu X; Li S; Li P; Pan W; Wang Q; Feng Y; Mo X; Yan Q; Ye X; Luo J; Qu L; Weber D; Byrne-Steele ML; Wang Z; Yu F; Li F; Myers RM; Lotze MT; Zhong N; Han J; Chen L Front Immunol 2020[]; 11 (ä): 582010 PMID33117392show ga Severe COVID-19 is associated with profound lymphopenia and an elevated neutrophil to lymphocyte ratio. We applied a novel dimer avoidance multiplexed polymerase chain reaction next-generation sequencing assay to analyze T (TCR) and B cell receptor (BCR) repertoires. Surprisingly, TCR repertoires were markedly diminished during the early onset of severe disease but recovered during the convalescent stage. Monitoring TCR repertoires could serve as an indicative biomarker to predict disease progression and recovery. Panoramic concurrent assessment of BCR repertoires demonstrated isotype switching and a transient but dramatic early IgA expansion. Dominant B cell clonal expansion with decreased diversity occurred following recovery from infection. Profound changes in T cell homeostasis raise critical questions about the early events in COVID-19 infection and demonstrate that immune repertoire analysis is a promising method for evaluating emergent host immunity to SARS-CoV-2 viral infection, with great implications for assessing vaccination and other immunological therapies. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |B-Lymphocytes/*immunology[MESH] |Betacoronavirus/*immunology[MESH] |CD4 Lymphocyte Count[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/pathology[MESH] |Female[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Humans[MESH] |Lymphopenia/pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/pathology[MESH] |Receptors, Antigen, B-Cell/*genetics[MESH] |Receptors, Antigen, T-Cell/*genetics[MESH] |SARS-CoV-2[MESH]Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts (epmc).pdf DeepDyve Pubget Overpricing