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10.3389/fimmu.2020.576745 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.576745 33117379!7575774!33117379     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 576745 Nephropedia Template TP {{tp|p=33117379|t=2020. ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 |pdf=|usr=}}{{33117379}} gab.com Text ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33117379 #FOAvip The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease is higher in elderly and co-morbid male patients. Therefore, the occurrence of specific comorbidities associated with renin-angiotensin system (RAS) imbalance mediated by the interaction between angiotensin-converting enzyme 2 (ACE2) and desintegrin and metalloproteinase domain 17 (ADAM17), along with specific genetic factors mainly associated with type II transmembrane serine protease (TMPRSS2) expression, could be decisive for the clinical outcome of COVID-19. Indeed, the exacerbated ADAM17-mediated ACE2, TNF-alpha, and IL-6R secretion emerges as a possible underlying mechanism for the acute inflammatory immune response and the activation of the coagulation cascade. Therefore, in this review, we focus on the main pathophysiological aspects of ACE2, ADAM17, and TMPRSS2 host proteins in COVID-19. Additionally, we discuss a possible mechanism to explain the deleterious effect of ADAM17 and TMPRSS2 over-activation in the COVID-19 outcome. Twit Text FOAVip ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33117379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33117379 #FOAvip English Wikipedia <ref>{{Cite pmid|33117379}}</ref> ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 #MMPMID33117379 Zipeto D; Palmeira JDF; Arganaraz GA; Arganaraz ER Front Immunol 2020[]; 11 (ä): 576745 PMID33117379show ga The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease is higher in elderly and co-morbid male patients. Therefore, the occurrence of specific comorbidities associated with renin-angiotensin system (RAS) imbalance mediated by the interaction between angiotensin-converting enzyme 2 (ACE2) and desintegrin and metalloproteinase domain 17 (ADAM17), along with specific genetic factors mainly associated with type II transmembrane serine protease (TMPRSS2) expression, could be decisive for the clinical outcome of COVID-19. Indeed, the exacerbated ADAM17-mediated ACE2, TNF-alpha, and IL-6R secretion emerges as a possible underlying mechanism for the acute inflammatory immune response and the activation of the coagulation cascade. Therefore, in this review, we focus on the main pathophysiological aspects of ACE2, ADAM17, and TMPRSS2 host proteins in COVID-19. Additionally, we discuss a possible mechanism to explain the deleterious effect of ADAM17 and TMPRSS2 over-activation in the COVID-19 outcome. |ADAM17 Protein/*metabolism[MESH] |Aged[MESH] |Aging[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronavirus Infections/*pathology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*metabolism[MESH] |Pneumonia, Viral/*pathology[MESH] |Receptors, Interleukin-6/metabolism[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/*metabolism[MESH]ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19(epmc).pdf DeepDyve Pubget Overpricing