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10.2147/IDR.S265718

http://scihub22266oqcxt.onion/10.2147/IDR.S265718
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33116692!7585866!33116692
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suck abstract from ncbi


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pmid33116692      Infect+Drug+Resist 2020 ; 13 (ä): 3715-3725
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  • Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection #MMPMID33116692
  • Gao YL; Du Y; Zhang C; Cheng C; Yang HY; Jin YF; Duan GC; Chen SY
  • Infect Drug Resist 2020[]; 13 (ä): 3715-3725 PMID33116692show ga
  • The renin-angiotensin system (RAS) is the most important regulatory system of electrolyte homeostasis and blood pressure and acts through angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/Ang II type 1 (AT1) receptor axis and angiotensin-converting enzyme 2 (ACE2)/angiotensin (1-7)/MAS receptor axis. RAS dysfunction is related to the occurrence and development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) and causes a serious prognosis and even death. ALI/ARDS can be induced by various ways, one of which is viral infections, such as SARS-CoV, SARS-CoV-2, H5N1, H7N9, and EV71. This article reviews the specific mechanism on how RAS dysfunction affects ALI/ARDs caused by viral infections. SARS-CoV and SARS-CoV-2 enter the host cells by binding with ACE2. H5N1 and H7N9 avian influenza viruses reduce the ACE2 level in the body, and EV71 increases Ang II concentration. Treatment with angiotensin-converting enzyme inhibitor and angiotensin AT1 receptor blocker can alleviate ALI/ARDS symptoms. This review provides suggestions for the treatment of lung injury caused by viral infections.
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