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10.1126/science.abd7728

http://scihub22266oqcxt.onion/10.1126/science.abd7728
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33115920!7810037!33115920
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suck abstract from ncbi


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pmid33115920      Science 2020 ; 370 (6521): 1227-1230
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  • Robust neutralizing antibodies to SARS-CoV-2 infection persist for months #MMPMID33115920
  • Wajnberg A; Amanat F; Firpo A; Altman DR; Bailey MJ; Mansour M; McMahon M; Meade P; Mendu DR; Muellers K; Stadlbauer D; Stone K; Strohmeier S; Simon V; Aberg J; Reich DL; Krammer F; Cordon-Cardo C
  • Science 2020[Dec]; 370 (6521): 1227-1230 PMID33115920show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with millions infected and more than 1 million fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here, on the basis of a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein. We also show that titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggest that more than 90% of seroconverters make detectable neutralizing antibody responses. These titers remain relatively stable for several months after infection.
  • |Antibodies, Neutralizing/blood/*immunology[MESH]
  • |Antibodies, Viral/blood/*immunology[MESH]
  • |COVID-19/blood/*immunology[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood/immunology[MESH]
  • |Neutralization Tests[MESH]


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