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10.1186/s12917-020-02627-6 http://scihub22266oqcxt.onion/10.1186/s12917-020-02627-6 33115475!7594293!33115475     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33115475&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       BMC+Vet+Res 2020 ; 16 (1): 408 Nephropedia Template TP {{tp|p=33115475|t=2020. Porcine interferon lambda 3 (IFN-lambda3) shows potent anti-PRRSV activity in primary porcine alveolar macrophages (PAMs) |pdf=|usr=}}{{33115475}} gab.com Text Porcine interferon lambda 3 (IFN-lambda3) shows potent anti-PRRSV activity in primary porcine alveolar macrophages (PAMs) JO: BMC Vet Res http://www.kidney.de/pget.php?&tw=1&pmid=33115475 #FOAvip BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) is a serious viral disease of swine. At present, there are vaccines for the control of PRRSV infection, but the effect is not satisfactory. The recombination of attenuated vaccines causes significant difficulties with the prevention and control of PRRSV. Type III interferons (IFNs), also called IFN-lambdas, were newly identified and showed potent antiviral activity within the mucosal surface and immune organs. RESULTS: Therefore, primary porcine alveolar macrophages (PAMs) were used for this investigation. To this end, we found that the replication of PRRSV in PAMs was significantly reduced after pre-treatment with IFN-lambda3, and such inhibition was dose- and time-dependent. The plaque formation of PRRSV abrogated entirely, and virus yields were reduced by four orders of magnitude when the primary PAMs were treated with IFN-lambda3 at 1000 ng/ml. In addition, IFN-lambda3 in our study was able to induce the expression of interferon-stimulated genes 15 (ISG15), 2'-5'-oligoadenylate synthase 1 (OAS1), IFN-inducible transmembrane 3 (IFITM3), and myxoma resistance protein 1(Mx1) in primary PAMs. CONCLUSIONS: IFN-lambda3 had antiviral activity against PRRSV and can stimulate the expression of pivotal interferon-stimulated genes (ISGs), i.e., ISG15, Mx1, OAS1, and IFITM3. So, IFN-lambda3 may serve as a useful antiviral agent. Twit Text FOAVip Porcine interferon lambda 3 (IFN-lambda3) shows potent anti-PRRSV activity in primary porcine alveolar macrophages (PAMs) ????BMC Vet Res http://www.kidney.de/pget.php?&tw=1&pmid=33115475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33115475 #FOAvip English Wikipedia <ref>{{Cite pmid|33115475}}</ref> Porcine interferon lambda 3 (IFN-lambda3) shows potent anti-PRRSV activity in primary porcine alveolar macrophages (PAMs) #MMPMID33115475 Zhao J; Zhu L; Xu L; Huang J; Sun X; Xu Z BMC Vet Res 2020[Oct]; 16 (1): 408 PMID33115475show ga BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) is a serious viral disease of swine. At present, there are vaccines for the control of PRRSV infection, but the effect is not satisfactory. The recombination of attenuated vaccines causes significant difficulties with the prevention and control of PRRSV. Type III interferons (IFNs), also called IFN-lambdas, were newly identified and showed potent antiviral activity within the mucosal surface and immune organs. RESULTS: Therefore, primary porcine alveolar macrophages (PAMs) were used for this investigation. To this end, we found that the replication of PRRSV in PAMs was significantly reduced after pre-treatment with IFN-lambda3, and such inhibition was dose- and time-dependent. The plaque formation of PRRSV abrogated entirely, and virus yields were reduced by four orders of magnitude when the primary PAMs were treated with IFN-lambda3 at 1000 ng/ml. In addition, IFN-lambda3 in our study was able to induce the expression of interferon-stimulated genes 15 (ISG15), 2'-5'-oligoadenylate synthase 1 (OAS1), IFN-inducible transmembrane 3 (IFITM3), and myxoma resistance protein 1(Mx1) in primary PAMs. CONCLUSIONS: IFN-lambda3 had antiviral activity against PRRSV and can stimulate the expression of pivotal interferon-stimulated genes (ISGs), i.e., ISG15, Mx1, OAS1, and IFITM3. So, IFN-lambda3 may serve as a useful antiviral agent. |Animals[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Interferon Lambda[MESH] |Interferons/*pharmacology[MESH] |Macrophages, Alveolar/*virology[MESH] |Porcine Reproductive and Respiratory Syndrome[MESH] |Porcine respiratory and reproductive syndrome virus/*drug effects[MESH] |Swine[MESH]Porcine interferon lambda 3 (IFN-lambda3) shows potent anti-PRRSV acti(epmc).pdf DeepDyve Pubget Overpricing