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10.3390/ijms21217948 http://scihub22266oqcxt.onion/10.3390/ijms21217948 33114717!7662367!33114717     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (21): ä Nephropedia Template TP {{tp|p=33114717|t=2020. Functional Diversity of Non-Histone Chromosomal Protein HmgB1 |pdf=|usr=}}{{33114717}} gab.com Text Functional Diversity of Non-Histone Chromosomal Protein HmgB1 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33114717 #FOAvip The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non-histone protein of the HMGB family-the HmgB1 protein. The proteins of the HMGB family are also known as "architectural factors" of chromatin, which play an important role in gene expression, transcription, DNA replication, and repair. However, as soon as HmgB1 goes outside the nucleus, it acquires completely different functions, post-translational modifications, and change of its redox state. Despite a lot of evidence of the functional activity of HmgB1, there are still many issues to be solved related to the mechanisms of the influence of HmgB1 on the development and treatment of different diseases-from oncological and cardiovascular diseases to pathologies during pregnancy and childbirth. Here, we describe molecular structure of the HmgB1 protein and discuss general mechanisms of its interactions with other proteins and DNA in cell. Twit Text FOAVip Functional Diversity of Non-Histone Chromosomal Protein HmgB1 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33114717 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33114717 #FOAvip English Wikipedia <ref>{{Cite pmid|33114717}}</ref> Functional Diversity of Non-Histone Chromosomal Protein HmgB1 #MMPMID33114717 Chikhirzhina E; Starkova T; Beljajev A; Polyanichko A; Tomilin A Int J Mol Sci 2020[Oct]; 21 (21): ä PMID33114717show ga The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non-histone protein of the HMGB family-the HmgB1 protein. The proteins of the HMGB family are also known as "architectural factors" of chromatin, which play an important role in gene expression, transcription, DNA replication, and repair. However, as soon as HmgB1 goes outside the nucleus, it acquires completely different functions, post-translational modifications, and change of its redox state. Despite a lot of evidence of the functional activity of HmgB1, there are still many issues to be solved related to the mechanisms of the influence of HmgB1 on the development and treatment of different diseases-from oncological and cardiovascular diseases to pathologies during pregnancy and childbirth. Here, we describe molecular structure of the HmgB1 protein and discuss general mechanisms of its interactions with other proteins and DNA in cell. |Animals[MESH] |Cardiovascular Diseases/*metabolism[MESH] |Chromatin/metabolism[MESH] |DNA Repair[MESH] |DNA Replication[MESH] |DNA/*metabolism[MESH] |Gene Expression Regulation[MESH] |HMGB1 Protein/*metabolism[MESH] |Humans[MESH] |Neoplasms/*metabolism[MESH] |Protein Processing, Post-Translational[MESH]Functional Diversity of Non-Histone Chromosomal Protein HmgB1 (epmc).pdf DeepDyve Pubget Overpricing