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10.3390/ijms21217937 http://scihub22266oqcxt.onion/10.3390/ijms21217937 33114676!7662856!33114676     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (21): ä Nephropedia Template TP {{tp|p=33114676|t=2020. Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19 |pdf=|usr=}}{{33114676}} gab.com Text Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33114676 #FOAvip Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the initiation of the immune response. The increased level of this cytokine in the elderly seems to be associated with the chronic inflammatory setting of the microenvironment in aged individuals. IL-6 also represents one of the main signals in communication between cancer cells and their non-malignant neighbours within the tumour niche. IL-6 also participates in the development of a premetastatic niche and in the adjustment of the metabolism in terminal-stage patients suffering from a malignant disease. IL-6 is a fundamental factor of the cytokine storm in patients with severe COVID-19, where it is responsible for the fatal outcome of the disease. A better understanding of the role of IL-6 under physiological as well as pathological conditions and the preparation of new strategies for the therapeutic control of the IL-6 axis may help to manage the problems associated with the elderly, cancer, and serious viral infections. Twit Text FOAVip Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33114676 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33114676 #FOAvip English Wikipedia <ref>{{Cite pmid|33114676}}</ref> Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19 #MMPMID33114676 Brabek J; Jakubek M; Vellieux F; Novotny J; Kolar M; Lacina L; Szabo P; Strnadova K; Rosel D; Dvorankova B; Smetana K Jr Int J Mol Sci 2020[Oct]; 21 (21): ä PMID33114676show ga Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the initiation of the immune response. The increased level of this cytokine in the elderly seems to be associated with the chronic inflammatory setting of the microenvironment in aged individuals. IL-6 also represents one of the main signals in communication between cancer cells and their non-malignant neighbours within the tumour niche. IL-6 also participates in the development of a premetastatic niche and in the adjustment of the metabolism in terminal-stage patients suffering from a malignant disease. IL-6 is a fundamental factor of the cytokine storm in patients with severe COVID-19, where it is responsible for the fatal outcome of the disease. A better understanding of the role of IL-6 under physiological as well as pathological conditions and the preparation of new strategies for the therapeutic control of the IL-6 axis may help to manage the problems associated with the elderly, cancer, and serious viral infections. |Aging/*metabolism/pathology[MESH] |Animals[MESH] |COVID-19[MESH] |Coronavirus Infections/*metabolism/pathology[MESH] |Humans[MESH] |Interleukin-6/genetics/*metabolism[MESH] |Neoplasms/*metabolism/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*metabolism/pathology[MESH]Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVI(epmc).pdf DeepDyve Pubget Overpricing