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10.3390/ph13110338 http://scihub22266oqcxt.onion/10.3390/ph13110338 33114370!7692516!33114370     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmaceuticals+(Basel) 2020 ; 13 (11): ä Nephropedia Template TP {{tp|p=33114370|t=2020. A Proline-Based Tectons and Supramolecular Synthons for Drug Design 2 0: A Case Study of ACEI |pdf=|usr=}}{{33114370}} gab.com Text A Proline-Based Tectons and Supramolecular Synthons for Drug Design 2 0: A Case Study of ACEI JO: Pharmaceuticals (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33114370 #FOAvip Proline is a unique, endogenous amino acid, prevalent in proteins and essential for living organisms. It is appreciated as a tecton for the rational design of new bio-active substances. Herein, we present a short overview of the subject. We analyzed 2366 proline-derived structures deposited in the Cambridge Structure Database, with emphasis on the angiotensin-converting enzyme inhibitors. The latter are the first-line antihypertensive and cardiological drugs. Their side effects prompt a search for improved pharmaceuticals. Characterization of tectons (molecular building blocks) and the resulting supramolecular synthons (patterns of intermolecular interactions) involving proline derivatives, as presented in this study, may be useful for in silico molecular docking and macromolecular modeling studies. The DFT, Hirshfeld surface and energy framework methods gave considerable insight into the nature of close inter-contacts and supramolecular topology. Substituents of proline entity are important for the formation and cooperation of synthons. Tectonic subunits contain proline moieties characterized by diverse ionization states: -N and -COOH(-COO(-)), -N(+) and -COOH(-COO(-)), -NH and -COOH(-COO(-)), -NH(+) and -COOH(-COO(-)), and -NH(2)(+) and -COOH(-COO(-)). Furthermore, pharmacological profiles of ACE inhibitors and their impurities were determined via an in silico approach. The above data were used to develop comprehensive classification, which may be useful in further drug design studies. Twit Text FOAVip A Proline-Based Tectons and Supramolecular Synthons for Drug Design 2 0: A Case Study of ACEI ????Pharmaceuticals (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33114370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33114370 #FOAvip English Wikipedia <ref>{{Cite pmid|33114370}}</ref> A Proline-Based Tectons and Supramolecular Synthons for Drug Design 2 0: A Case Study of ACEI #MMPMID33114370 Bojarska J; Remko M; Breza M; Madura I; Fruzinski A; Wolf WM Pharmaceuticals (Basel) 2020[Oct]; 13 (11): ä PMID33114370show ga Proline is a unique, endogenous amino acid, prevalent in proteins and essential for living organisms. It is appreciated as a tecton for the rational design of new bio-active substances. Herein, we present a short overview of the subject. We analyzed 2366 proline-derived structures deposited in the Cambridge Structure Database, with emphasis on the angiotensin-converting enzyme inhibitors. The latter are the first-line antihypertensive and cardiological drugs. Their side effects prompt a search for improved pharmaceuticals. Characterization of tectons (molecular building blocks) and the resulting supramolecular synthons (patterns of intermolecular interactions) involving proline derivatives, as presented in this study, may be useful for in silico molecular docking and macromolecular modeling studies. The DFT, Hirshfeld surface and energy framework methods gave considerable insight into the nature of close inter-contacts and supramolecular topology. Substituents of proline entity are important for the formation and cooperation of synthons. Tectonic subunits contain proline moieties characterized by diverse ionization states: -N and -COOH(-COO(-)), -N(+) and -COOH(-COO(-)), -NH and -COOH(-COO(-)), -NH(+) and -COOH(-COO(-)), and -NH(2)(+) and -COOH(-COO(-)). Furthermore, pharmacological profiles of ACE inhibitors and their impurities were determined via an in silico approach. The above data were used to develop comprehensive classification, which may be useful in further drug design studies. äA Proline-Based Tectons and Supramolecular Synthons for Drug Design 2 (epmc).pdf DeepDyve Pubget Overpricing