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10.1016/j.cyto.2020.155354 http://scihub22266oqcxt.onion/10.1016/j.cyto.2020.155354 33113474!ä!33113474 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cytokine 2021 ; 137 (ä): 155354 Nephropedia Template TP {{tp|p=33113474|t=2021. The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19 |pdf=|usr=}}{{33113474}} gab.com Text The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19 JO: Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=33113474 #FOAvip BACKGROUND AND AIMS: The interferon-induced transmembrane proteins play an important antiviral role by preventing viruses from traversing the cellular lipid bilayer. IFITM3 gene variants have been associated with the clinical response to influenza and other viruses. Our aim was to determine whether the IFITM3 rs12252 polymorphism was associated with the risk of developing severe symptoms of COVID-19 in our population. METHODS: A total of 288 COVID-19 patients who required hospitalization (81 in the intensive care unit) and 440 age matched controls were genotyped with a Taqman assay. Linear regression models were used to compare allele and genotype frequencies between the groups, correcting for age and sex. RESULTS: Carriers of the minor allele frequency (rs12252 C) were significantly more frequent in the patients compared to controls after correcting by age and sex (p = 0.01, OR = 2.02, 95%CI = 1.19-3.42). This genotype was non-significantly more common among patients who required ICU. CONCLUSIONS: The IFITM3 rs12252 C allele was a risk factor for COVID-19 hospitalization in our Caucasian population. The extent of the association was lower than the reported among Chinese, a population with a much higher frequency of the risk allele. Twit Text FOAVip The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19 ????Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=33113474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33113474 #FOAvip English Wikipedia <ref>{{Cite pmid|33113474}}</ref> The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19 #MMPMID33113474 Gomez J; Albaiceta GM; Cuesta-Llavona E; Garcia-Clemente M; Lopez-Larrea C; Amado-Rodriguez L; Lopez-Alonso I; Melon S; Alvarez-Arguelles ME; Gil-Pena H; Vidal-Castineira JR; Corte-Iglesias V; Saiz ML; Alvarez V; Coto E Cytokine 2021[Jan]; 137 (ä): 155354 PMID33113474show ga BACKGROUND AND AIMS: The interferon-induced transmembrane proteins play an important antiviral role by preventing viruses from traversing the cellular lipid bilayer. IFITM3 gene variants have been associated with the clinical response to influenza and other viruses. Our aim was to determine whether the IFITM3 rs12252 polymorphism was associated with the risk of developing severe symptoms of COVID-19 in our population. METHODS: A total of 288 COVID-19 patients who required hospitalization (81 in the intensive care unit) and 440 age matched controls were genotyped with a Taqman assay. Linear regression models were used to compare allele and genotype frequencies between the groups, correcting for age and sex. RESULTS: Carriers of the minor allele frequency (rs12252 C) were significantly more frequent in the patients compared to controls after correcting by age and sex (p = 0.01, OR = 2.02, 95%CI = 1.19-3.42). This genotype was non-significantly more common among patients who required ICU. CONCLUSIONS: The IFITM3 rs12252 C allele was a risk factor for COVID-19 hospitalization in our Caucasian population. The extent of the association was lower than the reported among Chinese, a population with a much higher frequency of the risk allele. |Aged[MESH] |Asian People/*genetics[MESH] |COVID-19/blood/epidemiology/*genetics[MESH] |Female[MESH] |Gene Frequency[MESH] |Genetic Predisposition to Disease[MESH] |Genotype[MESH] |Humans[MESH] |Linear Models[MESH] |Male[MESH] |Membrane Proteins/blood/*genetics[MESH] |Middle Aged[MESH] |Polymorphism, Genetic[MESH] |RNA-Binding Proteins/blood/*genetics[MESH] |Risk Factors[MESH]The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C(epmc).pdf DeepDyve Pubget Overpricing