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10.15252/embr.202051252 http://scihub22266oqcxt.onion/10.15252/embr.202051252 33112036!7645910!33112036     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2020 ; 21 (12): e51252 Nephropedia Template TP {{tp|p=33112036|t=2020. SARS-CoV-2 evades immune detection in alveolar macrophages |pdf=|usr=}}{{33112036}} gab.com Text SARS-CoV-2 evades immune detection in alveolar macrophages JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=33112036 #FOAvip Respiratory infections, like the current COVID-19 pandemic, target epithelial cells in the respiratory tract. Alveolar macrophages (AMs) are tissue-resident macrophages located within the lung. They play a key role in the early phases of an immune response to respiratory viruses. AMs are likely the first immune cells to encounter SARS-CoV-2 during an infection, and their reaction to the virus will have a profound impact on the outcome of the infection. Interferons (IFNs) are antiviral cytokines and among the first cytokines produced upon viral infection. In this study, AMs from non-infectious donors are challenged with SARS-CoV-2. We demonstrate that challenged AMs are incapable of sensing SARS-CoV-2 and of producing an IFN response in contrast to other respiratory viruses, like influenza A virus and Sendai virus, which trigger a robust IFN response. The absence of IFN production in AMs upon challenge with SARS-CoV-2 could explain the initial asymptotic phase observed during COVID-19 and argues against AMs being the sources of pro-inflammatory cytokines later during infection. Twit Text FOAVip SARS-CoV-2 evades immune detection in alveolar macrophages ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=33112036 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33112036 #FOAvip English Wikipedia <ref>{{Cite pmid|33112036}}</ref> SARS-CoV-2 evades immune detection in alveolar macrophages #MMPMID33112036 Dalskov L; Mohlenberg M; Thyrsted J; Blay-Cadanet J; Poulsen ET; Folkersen BH; Skaarup SH; Olagnier D; Reinert L; Enghild JJ; Hoffmann HJ; Holm CK; Hartmann R EMBO Rep 2020[Dec]; 21 (12): e51252 PMID33112036show ga Respiratory infections, like the current COVID-19 pandemic, target epithelial cells in the respiratory tract. Alveolar macrophages (AMs) are tissue-resident macrophages located within the lung. They play a key role in the early phases of an immune response to respiratory viruses. AMs are likely the first immune cells to encounter SARS-CoV-2 during an infection, and their reaction to the virus will have a profound impact on the outcome of the infection. Interferons (IFNs) are antiviral cytokines and among the first cytokines produced upon viral infection. In this study, AMs from non-infectious donors are challenged with SARS-CoV-2. We demonstrate that challenged AMs are incapable of sensing SARS-CoV-2 and of producing an IFN response in contrast to other respiratory viruses, like influenza A virus and Sendai virus, which trigger a robust IFN response. The absence of IFN production in AMs upon challenge with SARS-CoV-2 could explain the initial asymptotic phase observed during COVID-19 and argues against AMs being the sources of pro-inflammatory cytokines later during infection. |Antiviral Agents/immunology[MESH] |COVID-19/*immunology/virology[MESH] |Cells, Cultured[MESH] |Cytokines/immunology[MESH] |Epithelial Cells/immunology/virology[MESH] |Humans[MESH] |Immune Evasion[MESH] |Interferon Type I/immunology[MESH] |Lung/immunology/virology[MESH] |Macrophages, Alveolar/*immunology/*virology[MESH] |Pandemics[MESH]SARS-CoV-2 evades immune detection in alveolar macrophages (epmc).pdf DeepDyve Pubget Overpricing