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10.1177/0885066620969132

http://scihub22266oqcxt.onion/10.1177/0885066620969132
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33111601!ä!33111601

suck abstract from ncbi


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pmid33111601      J+Intensive+Care+Med 2021 ; 36 (1): 18-41
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  • Evidence-Based Management of the Critically Ill Adult With SARS-CoV-2 Infection #MMPMID33111601
  • Chivukula RR; Maley JH; Dudzinski DM; Hibbert K; Hardin CC
  • J Intensive Care Med 2021[Jan]; 36 (1): 18-41 PMID33111601show ga
  • Human infection by the novel viral pathogen SARS-CoV-2 results in a clinical syndrome termed Coronavirus Disease 2019 (COVID-19). Although the majority of COVID-19 cases are self-limiting, a substantial minority of patients develop disease severe enough to require intensive care. Features of critical illness associated with COVID-19 include hypoxemic respiratory failure, acute respiratory distress syndrome (ARDS), shock, and multiple organ dysfunction syndrome (MODS). In most (but not all) respects critically ill patients with COVID-19 resemble critically ill patients with ARDS due to other causes and are optimally managed with standard, evidence-based critical care protocols. However, there is naturally an intense interest in developing specific therapies for severe COVID-19. Here we synthesize the rapidly expanding literature around the pathophysiology, clinical presentation, and management of COVID-19 with a focus on those points most relevant for intensivists tasked with caring for these patients. We specifically highlight evidence-based approaches that we believe should guide the identification, triage, respiratory support, and general ICU care of critically ill patients infected with SARS-CoV-2. In addition, in light of the pressing need and growing enthusiasm for targeted COVID-19 therapies, we review the biological basis, plausibility, and clinical evidence underlying these novel treatment approaches.
  • |Adult[MESH]
  • |COVID-19/complications/physiopathology/*therapy[MESH]
  • |Critical Care/*methods[MESH]
  • |Critical Illness/*therapy[MESH]
  • |Evidence-Based Practice/methods[MESH]
  • |Humans[MESH]


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