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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+Rev+Immunol 2021 ; 40 (1-2): 54-71 Nephropedia Template TP
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Pathogenesis guided therapeutic management of COVID-19: an immunological perspective #MMPMID33111578
Kumar A; Prasoon P; Sekhawat PS; Pareek V; Faiq MA; Kumari C; Narayan RK; Kulandhasamy M; Kant K
Int Rev Immunol 2021[]; 40 (1-2): 54-71 PMID33111578show ga
Lack of standardized therapeutic approaches is arguably the significant contributor to the high burden of mortality observed in the ongoing pandemic of the Coronavirus disease, 2019 (COVID-19). Evidence is accumulating on SARS-CoV-2 specific immune cell dysregulation and consequent tissue injury in COVID-19. Currently, no definite drugs or vaccines are available against the disease; however initial results of the ongoing clinical trials have raised some hope. In this article, taking insights from the emerging empirical evidence about host-virus interactions, we deliberate upon plausible pathogenic mechanisms and suitable therapeutic approaches for COVID-19.