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10.1007/s12308-020-00423-7

http://scihub22266oqcxt.onion/10.1007/s12308-020-00423-7
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33110452!7581498!33110452
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suck abstract from ncbi


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pmid33110452      J+Hematop 2021 ; 14 (1): 79-83
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  • Case report: a fatal combination of hemophagocytic lymphohistiocytosis with extensive pulmonary microvascular damage in COVID-19 pneumonia #MMPMID33110452
  • von der Thusen JH; van Bommel J; Kros JM; Verdijk RM; Lopuhaa B; Lam KH; Dik WA; Miedema JR
  • J Hematop 2021[Mar]; 14 (1): 79-83 PMID33110452show ga
  • The clinical features of COVID-19 have a considerable range from a mild illness to severe disease. Underlying pathophysiological mechanisms of the rapidly progressive, and often fatal, pulmonary disease frequently observed in COVID-19 need to be elucidated, in order to develop new treatment strategies for different disease endotypes. Fatal cases can display features of a cytokine storm, which may be related to hemophagocytic lymphohistiocytosis. Also, a spectrum of vascular changes, including microvascular damage, is known to accompany severe COVID-19. In this paper, we describe the co-occurrence of hemophagocytic lymphohistiocytosis and extensive pulmonary microvascular damage with thrombosis and its sequelae in a patient with fatal COVID-19. We believe these response patterns may be linked by common mechanisms involving hypercytokinemia and require further investigation as a fatal constellation in COVID-19, to generate appropriate treatment in patients who display these combined features.
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