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10.1038/s41423-020-00571-x http://scihub22266oqcxt.onion/10.1038/s41423-020-00571-x 33110251!7588591!33110251     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Immunol 2021 ; 18 (3): 613-620 Nephropedia Template TP {{tp|p=33110251|t=2021. SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response |pdf=|usr=}}{{33110251}} gab.com Text SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33110251 #FOAvip A novel SARS-related coronavirus (SARS-CoV-2) has recently emerged as a serious pathogen that causes high morbidity and substantial mortality. However, the mechanisms by which SARS-CoV-2 evades host immunity remain poorly understood. Here, we identified SARS-CoV-2 membrane glycoprotein M as a negative regulator of the innate immune response. We found that the M protein interacted with the central adaptor protein MAVS in the innate immune response pathways. This interaction impaired MAVS aggregation and its recruitment of downstream TRAF3, TBK1, and IRF3, leading to attenuation of the innate antiviral response. Our findings reveal a mechanism by which SARS-CoV-2 evades the innate immune response and suggest that the M protein of SARS-CoV-2 is a potential target for the development of SARS-CoV-2 interventions. Twit Text FOAVip SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33110251 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33110251 #FOAvip English Wikipedia <ref>{{Cite pmid|33110251}}</ref> SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response #MMPMID33110251 Fu YZ; Wang SY; Zheng ZQ; Yi Huang; Li WW; Xu ZS; Wang YY Cell Mol Immunol 2021[Mar]; 18 (3): 613-620 PMID33110251show ga A novel SARS-related coronavirus (SARS-CoV-2) has recently emerged as a serious pathogen that causes high morbidity and substantial mortality. However, the mechanisms by which SARS-CoV-2 evades host immunity remain poorly understood. Here, we identified SARS-CoV-2 membrane glycoprotein M as a negative regulator of the innate immune response. We found that the M protein interacted with the central adaptor protein MAVS in the innate immune response pathways. This interaction impaired MAVS aggregation and its recruitment of downstream TRAF3, TBK1, and IRF3, leading to attenuation of the innate antiviral response. Our findings reveal a mechanism by which SARS-CoV-2 evades the innate immune response and suggest that the M protein of SARS-CoV-2 is a potential target for the development of SARS-CoV-2 interventions. |*Immunity, Innate[MESH] |Adaptor Proteins, Signal Transducing/*immunology[MESH] |COVID-19/*immunology[MESH] |HEK293 Cells[MESH] |HeLa Cells[MESH] |Humans[MESH] |SARS-CoV-2/*immunology[MESH] |Signal Transduction/*immunology[MESH]SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innat(epmc).pdf DeepDyve Pubget Overpricing