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10.1038/s41419-020-03125-1 http://scihub22266oqcxt.onion/10.1038/s41419-020-03125-1 33110074!7590570!33110074     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2020 ; 11 (10): 921 Nephropedia Template TP {{tp|p=33110074|t=2020. Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome |pdf=|usr=}}{{33110074}} gab.com Text Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=33110074 #FOAvip The immunological mechanisms underlying the clinical presentation of SARS-CoV-2 infection and those influencing the disease outcome remain to be defined. Myeloid-derived suppressor cells (MDSC) have been described to be highly increased during COVID-19, however, their role remains elusive. We performed an in depth analysis of MDSC in 128 SARS-CoV-2 infected patients. Polymorphonuclear (PMN)-MDSC expanded during COVID-19, in particular in patients who required intensive care treatments, and correlated with IL-1beta, IL-6, IL-8, and TNF-alpha plasma levels. PMN-MDSC inhibited T-cells IFN-gamma production upon SARS-CoV-2 peptides stimulation, through TGF-beta- and iNOS-mediated mechanisms, possibly contrasting virus elimination. Accordingly, a multivariate regression analysis found a strong association between PMN-MDSC percentage and fatal outcome of the disease. The PMN-MDSC frequency was higher in non-survivors than survivors at the admission time, followed by a decreasing trend. Interestingly, this trend was associated with IL-6 increase in non-survivors but not in survivors. In conclusion, this study indicates PMN-MDSC as a novel factor in the pathogenesis of SARS-CoV2 infection, and open up to new therapeutic options. Twit Text FOAVip Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=33110074 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33110074 #FOAvip English Wikipedia <ref>{{Cite pmid|33110074}}</ref> Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome #MMPMID33110074 Sacchi A; Grassi G; Bordoni V; Lorenzini P; Cimini E; Casetti R; Tartaglia E; Marchioni L; Petrosillo N; Palmieri F; D'Offizi G; Notari S; Tempestilli M; Capobianchi MR; Nicastri E; Maeurer M; Zumla A; Locatelli F; Antinori A; Ippolito G; Agrati C Cell Death Dis 2020[Oct]; 11 (10): 921 PMID33110074show ga The immunological mechanisms underlying the clinical presentation of SARS-CoV-2 infection and those influencing the disease outcome remain to be defined. Myeloid-derived suppressor cells (MDSC) have been described to be highly increased during COVID-19, however, their role remains elusive. We performed an in depth analysis of MDSC in 128 SARS-CoV-2 infected patients. Polymorphonuclear (PMN)-MDSC expanded during COVID-19, in particular in patients who required intensive care treatments, and correlated with IL-1beta, IL-6, IL-8, and TNF-alpha plasma levels. PMN-MDSC inhibited T-cells IFN-gamma production upon SARS-CoV-2 peptides stimulation, through TGF-beta- and iNOS-mediated mechanisms, possibly contrasting virus elimination. Accordingly, a multivariate regression analysis found a strong association between PMN-MDSC percentage and fatal outcome of the disease. The PMN-MDSC frequency was higher in non-survivors than survivors at the admission time, followed by a decreasing trend. Interestingly, this trend was associated with IL-6 increase in non-survivors but not in survivors. In conclusion, this study indicates PMN-MDSC as a novel factor in the pathogenesis of SARS-CoV2 infection, and open up to new therapeutic options. |Aged[MESH] |Area Under Curve[MESH] |Betacoronavirus/*immunology/isolation & purification/metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/mortality/*pathology/virology[MESH] |Female[MESH] |Humans[MESH] |Interferon-gamma/metabolism[MESH] |Interleukin-1beta/blood[MESH] |Interleukin-6/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Myeloid-Derived Suppressor Cells/cytology/*immunology[MESH] |Neutrophils/cytology/immunology/metabolism[MESH] |Nitric Oxide Synthase Type II/metabolism[MESH] |Pandemics[MESH] |Peptides/immunology/metabolism[MESH] |Pneumonia, Viral/immunology/mortality/*pathology/virology[MESH] |Proportional Hazards Models[MESH] |ROC Curve[MESH] |SARS-CoV-2[MESH] |Survival Rate[MESH] |T-Lymphocytes/cytology/*immunology/metabolism[MESH]Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing