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10.1128/mBio.02623-20 http://scihub22266oqcxt.onion/10.1128/mBio.02623-20 33109765!7593974!33109765     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       mBio 2020 ; 11 (5): ä Nephropedia Template TP {{tp|p=33109765|t=2020. DDX56 Binds to Chikungunya Virus RNA To Control Infection |pdf=|usr=}}{{33109765}} gab.com Text DDX56 Binds to Chikungunya Virus RNA To Control Infection JO: mBio http://www.kidney.de/pget.php?&tw=1&pmid=33109765 #FOAvip DEAD box RNA helicases regulate diverse facets of RNA biology. Proteins of this family carry out essential cellular functions, and emerging literature is revealing additional roles in immune defense. Using RNA interference screening, we identified an evolutionarily conserved antiviral role for the helicase DDX56 against the alphavirus Sindbis virus (SINV), a mosquito-transmitted pathogen that infects humans. Depletion of DDX56 enhanced infection in Drosophila and human cells. Furthermore, we found that DDX56 also controls the emerging alphavirus chikungunya virus (CHIKV) through an interferon-independent mechanism. Using cross-linking immunoprecipitation (CLIP-Seq), we identified a predicted stem-loop on the viral genomic RNA bound by DDX56. Mechanistically, we found that DDX56 levels increase in the cytoplasm during CHIKV infection. In the cytoplasm, DDX56 impacts the earliest step in the viral replication cycle by binding and destabilizing the incoming viral genomic RNA, thereby attenuating infection. Thus, DDX56 is a conserved antiviral RNA binding protein that controls alphavirus infection.IMPORTANCE Arthropod-borne viruses are diverse pathogens and include the emerging virus chikungunya virus, which is associated with human disease. Through genetic screening, we found that the conserved RNA binding protein DDX56 is antiviral against chikungunya virus in insects and humans. DDX56 relocalizes from the nucleus to the cytoplasm, where it binds to a stem-loop in the viral genome and destabilizes incoming genomes. Thus, DDX56 is an evolutionarily conserved antiviral factor that controls alphavirus infection. Twit Text FOAVip DDX56 Binds to Chikungunya Virus RNA To Control Infection ????mBio http://www.kidney.de/pget.php?&tw=1&pmid=33109765 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33109765 #FOAvip English Wikipedia <ref>{{Cite pmid|33109765}}</ref> DDX56 Binds to Chikungunya Virus RNA To Control Infection #MMPMID33109765 Taschuk F; Tapescu I; Moy RH; Cherry S mBio 2020[Oct]; 11 (5): ä PMID33109765show ga DEAD box RNA helicases regulate diverse facets of RNA biology. Proteins of this family carry out essential cellular functions, and emerging literature is revealing additional roles in immune defense. Using RNA interference screening, we identified an evolutionarily conserved antiviral role for the helicase DDX56 against the alphavirus Sindbis virus (SINV), a mosquito-transmitted pathogen that infects humans. Depletion of DDX56 enhanced infection in Drosophila and human cells. Furthermore, we found that DDX56 also controls the emerging alphavirus chikungunya virus (CHIKV) through an interferon-independent mechanism. Using cross-linking immunoprecipitation (CLIP-Seq), we identified a predicted stem-loop on the viral genomic RNA bound by DDX56. Mechanistically, we found that DDX56 levels increase in the cytoplasm during CHIKV infection. In the cytoplasm, DDX56 impacts the earliest step in the viral replication cycle by binding and destabilizing the incoming viral genomic RNA, thereby attenuating infection. Thus, DDX56 is a conserved antiviral RNA binding protein that controls alphavirus infection.IMPORTANCE Arthropod-borne viruses are diverse pathogens and include the emerging virus chikungunya virus, which is associated with human disease. Through genetic screening, we found that the conserved RNA binding protein DDX56 is antiviral against chikungunya virus in insects and humans. DDX56 relocalizes from the nucleus to the cytoplasm, where it binds to a stem-loop in the viral genome and destabilizes incoming genomes. Thus, DDX56 is an evolutionarily conserved antiviral factor that controls alphavirus infection. |*Host-Pathogen Interactions[MESH] |Cell Line, Tumor[MESH] |Chikungunya Fever[MESH] |Chikungunya virus[MESH] |DEAD-box RNA Helicases/*metabolism[MESH] |Genomics[MESH] |HeLa Cells[MESH] |Humans[MESH] |Osteosarcoma[MESH] |Protein Binding[MESH] |RNA Interference[MESH] |RNA, Viral/*metabolism[MESH]DDX56 Binds to Chikungunya Virus RNA To Control Infection (epmc).pdf DeepDyve Pubget Overpricing