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10.1017/S2045796020000992 http://scihub22266oqcxt.onion/10.1017/S2045796020000992 33109299!7674786!33109299     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epidemiol+Psychiatr+Sci 2020 ; 29 (ä): e184 Nephropedia Template TP {{tp|p=33109299|t=2020. Preserving equipoise and performing randomised trials for COVID-19 social distancing interventions |pdf=|usr=}}{{33109299}} gab.com Text Preserving equipoise and performing randomised trials for COVID-19 social distancing interventions JO: Epidemiol Psychiatr Sci http://www.kidney.de/pget.php?&tw=1&pmid=33109299 #FOAvip In the coronavirus disease 2019 (COVID-19) pandemic, a large number of non-pharmaceutical measures that pertain to the wider group of social distancing interventions (e.g. public gathering bans, closures of schools, workplaces and all but essential business, mandatory stay-at-home policies, travel restrictions, border closures and others) have been deployed. Their urgent deployment was defended with modelling and observational data of spurious credibility. There is major debate on whether these measures are effective and there is also uncertainty about the magnitude of the harms that these measures might induce. Given that there is equipoise for how, when and if specific social distancing interventions for COVID-19 should be applied and removed/modified during reopening, we argue that informative randomised-controlled trials are needed. Only a few such randomised trials have already been conducted, but the ones done to-date demonstrate that a randomised trials agenda is feasible. We discuss here issues of study design choice, selection of comparators (intervention and controls), choice of outcomes and additional considerations for the conduct of such trials. We also discuss and refute common counter-arguments against the conduct of such trials. Twit Text FOAVip Preserving equipoise and performing randomised trials for COVID-19 social distancing interventions ????Epidemiol Psychiatr Sci http://www.kidney.de/pget.php?&tw=1&pmid=33109299 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33109299 #FOAvip English Wikipedia <ref>{{Cite pmid|33109299}}</ref> Preserving equipoise and performing randomised trials for COVID-19 social distancing interventions #MMPMID33109299 Cristea IA; Naudet F; Ioannidis JPA Epidemiol Psychiatr Sci 2020[Oct]; 29 (ä): e184 PMID33109299show ga In the coronavirus disease 2019 (COVID-19) pandemic, a large number of non-pharmaceutical measures that pertain to the wider group of social distancing interventions (e.g. public gathering bans, closures of schools, workplaces and all but essential business, mandatory stay-at-home policies, travel restrictions, border closures and others) have been deployed. Their urgent deployment was defended with modelling and observational data of spurious credibility. There is major debate on whether these measures are effective and there is also uncertainty about the magnitude of the harms that these measures might induce. Given that there is equipoise for how, when and if specific social distancing interventions for COVID-19 should be applied and removed/modified during reopening, we argue that informative randomised-controlled trials are needed. Only a few such randomised trials have already been conducted, but the ones done to-date demonstrate that a randomised trials agenda is feasible. We discuss here issues of study design choice, selection of comparators (intervention and controls), choice of outcomes and additional considerations for the conduct of such trials. We also discuss and refute common counter-arguments against the conduct of such trials. |*Coronavirus[MESH] |*Pandemics[MESH] |*Psychological Distance[MESH] |*Randomized Controlled Trials as Topic[MESH] |*Therapeutic Equipoise[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology[MESH] |Humans[MESH] |Pneumonia, Viral/epidemiology[MESH] |Research Design[MESH] |SARS-CoV-2[MESH]Preserving equipoise and performing randomised trials for COVID-19 soc(epmc).pdf DeepDyve Pubget Overpricing