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10.1007/s43440-020-00175-2

http://scihub22266oqcxt.onion/10.1007/s43440-020-00175-2
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33108587!7590246!33108587
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suck abstract from ncbi

pmid33108587      Pharmacol+Rep 2020 ; 72 (6): 1542-1552
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  • Favipiravir use for SARS CoV-2 infection #MMPMID33108587
  • Boretti A
  • Pharmacol Rep 2020[Dec]; 72 (6): 1542-1552 PMID33108587show ga
  • INTRODUCTION: The pandemic of SARS CoV-2 has required urgent medical treatments for numerous patients. As no specific antiviral agents were available, different off-the-shelf alternatives have been explored. OBJECTIVE: Here, we review the rationale behind the use of Favipiravir, and report of the specific studies supporting this treatment being conducted. METHODS: Here we analyze the relevant literature to conclude about the present opportunities offered by this therapeutic agent. RESULTS: This antiviral drug approved influenza in Japan since 2014, has a demonstrated in vitro activity against SARS CoV-2 and is being investigated in several trials for SARS CoV-2. Signals of benefit were shown in a small trial for SARS CoV-2. However, in another small study, there was no advantage. CONCLUSIONS: Further studies, statistically more significant, are urgently needed to understand the best opportunities offered by this treatment.
  • |*COVID-19 Drug Treatment[MESH]
  • |Amides/*therapeutic use[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |COVID-19/virology[MESH]
  • |Humans[MESH]
  • |Pyrazines/*therapeutic use[MESH]
  • |SARS-CoV-2/drug effects/isolation & purification[MESH]


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