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10.1007/s11684-020-0820-7

http://scihub22266oqcxt.onion/10.1007/s11684-020-0820-7
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33106939!7587538!33106939
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suck abstract from ncbi


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pmid33106939      Front+Med 2020 ; 14 (6): 776-785
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  • Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19 #MMPMID33106939
  • Cai X; Jiang H; Zhang S; Xia S; Du W; Ma Y; Yu T; Li W
  • Front Med 2020[Dec]; 14 (6): 776-785 PMID33106939show ga
  • Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread around the world. However, approaches to distinguish COVID-19 from pneumonia caused by other pathogens have not yet been reported. We retrospectively analyzed the clinical data of 97 children with probable COVID-19. A total of 13 (13.4%) patients were confirmed positive for SARS-CoV-2 infection by nucleic acid RT-PCR testing, and 41 (42.3%) patients were found to be infected with other pathogens. Notably, no pathogen was detected in 43 (44.3%) patients. Among all patients, 25 (25.8%) had familial cluster exposure history, and 52 (53.6%) had one or more coexisting conditions. Fifteen (15.5%) patients were admitted or transferred to the PICU. In the 11 confirmed COVID-19 cases, 5 (45.5%) and 7 (63.6%) were positive for IgM and IgG against SARS-CoV-2, respectively. In 22 patients with suspected COVID-19, 1 (4.5%) was positive for IgG but negative for IgM. The most frequently detected pathogen was Mycoplasma pneumonia (29, 29.9%). One patient with confirmed COVID-19 died. Our results strongly indicated that the detection of asymptomatic COVID-19 or coexisting conditions must be strengthened in pediatric patients. These cases may be difficult to diagnose as COVID-19 unless etiologic analysis is conducted. A serologic test can be a useful adjunctive diagnostic tool in cases where SARS-CoV-2 infection is highly suspected but the nucleic acid test is negative.
  • |*COVID-19 Testing[MESH]
  • |Age Factors[MESH]
  • |COVID-19/*complications/*diagnosis[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |China[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*isolation & purification[MESH]


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