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10.1101/2020.10.17.344002 http://scihub22266oqcxt.onion/10.1101/2020.10.17.344002 33106807!7587781!33106807     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33106807&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       bioRxiv 2021 ; ? (?): ? Nephropedia Template TP {{tp|p=33106807|t=2021. Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19 |pdf=|usr=}}{{33106807}} gab.com Text Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19 JO: bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33106807 #FOAvip SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains unclear. We present a scalable, propagable, personalized, cost-effective adult stem cell-derived human lung organoid model that is complete with both proximal and distal airway epithelia. Monolayers derived from adult lung organoids (ALOs), primary airway cells, or hiPSC-derived alveolar type-II (AT2) pneumocytes were infected with SARS-CoV-2 to create in vitro lung models of COVID-19. Infected ALO-monolayers best recapitulated the transcriptomic signatures in diverse cohorts of COVID-19 patient-derived respiratory samples. The airway (proximal) cells were critical for sustained viral infection whereas distal alveolar differentiation (AT2-->AT1) was critical for mounting the overzealous host immune response in fatal disease; ALO monolayers with well-mixed proximodistal airway components recapitulated both. Findings validate a human lung model of COVID-19 which can be immediately utilized to investigate COVID-19 pathogenesis, and vet new therapies and vaccines. Twit Text FOAVip Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19 ????bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33106807 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33106807 #FOAvip English Wikipedia <ref>{{Cite pmid|33106807}}</ref> Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19 #MMPMID33106807 Tindle C; Fuller M; Fonseca A; Taheri S; Ibeawuchi SR; Beutler N; Katkar G; Claire A; Castillo V; Hernandez M; Russo H; Duran J; Crotty Alexander LE; Tipps A; Lin G; Thistlethwaite PA; Chattopadhyay R; Rogers TF; Sahoo D; Ghosh P; Das S bioRxiv 2021[May]; ? (?): ? PMID33106807show ga SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains unclear. We present a scalable, propagable, personalized, cost-effective adult stem cell-derived human lung organoid model that is complete with both proximal and distal airway epithelia. Monolayers derived from adult lung organoids (ALOs), primary airway cells, or hiPSC-derived alveolar type-II (AT2) pneumocytes were infected with SARS-CoV-2 to create in vitro lung models of COVID-19. Infected ALO-monolayers best recapitulated the transcriptomic signatures in diverse cohorts of COVID-19 patient-derived respiratory samples. The airway (proximal) cells were critical for sustained viral infection whereas distal alveolar differentiation (AT2-->AT1) was critical for mounting the overzealous host immune response in fatal disease; ALO monolayers with well-mixed proximodistal airway components recapitulated both. Findings validate a human lung model of COVID-19 which can be immediately utilized to investigate COVID-19 pathogenesis, and vet new therapies and vaccines. ?Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Dis(epmc).pdf DeepDyve Pubget Overpricing