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10.1038/s41596-020-00403-2 http://scihub22266oqcxt.onion/10.1038/s41596-020-00403-2 33106680!7704938!33106680     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Protoc 2020 ; 15 (12): 3777-3787 Nephropedia Template TP {{tp|p=33106680|t=2020. Genetically modified mouse models to help fight COVID-19 |pdf=|usr=}}{{33106680}} gab.com Text Genetically modified mouse models to help fight COVID-19 JO: Nat Protoc http://www.kidney.de/pget.php?&tw=1&pmid=33106680 #FOAvip The research community is in a race to understand the molecular mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently available antiviral drugs and to develop new therapies and vaccines against coronavirus disease 2019 (COVID-19). One major challenge in achieving these goals is the paucity of suitable preclinical animal models. Mice constitute ~70% of all the laboratory animal species used in biomedical research. Unfortunately, SARS-CoV-2 infects mice only if they have been genetically modified to express human ACE2. The inherent resistance of wild-type mice to SARS-CoV-2, combined with a wealth of genetic tools that are available only for modifying mice, offers a unique opportunity to create a versatile set of genetically engineered mouse models useful for COVID-19 research. We propose three broad categories of these models and more than two dozen designs that may be useful for SARS-CoV-2 research and for fighting COVID-19. Twit Text FOAVip Genetically modified mouse models to help fight COVID-19 ????Nat Protoc http://www.kidney.de/pget.php?&tw=1&pmid=33106680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33106680 #FOAvip English Wikipedia <ref>{{Cite pmid|33106680}}</ref> Genetically modified mouse models to help fight COVID-19 #MMPMID33106680 Gurumurthy CB; Quadros RM; Richardson GP; Poluektova LY; Mansour SL; Ohtsuka M Nat Protoc 2020[Dec]; 15 (12): 3777-3787 PMID33106680show ga The research community is in a race to understand the molecular mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently available antiviral drugs and to develop new therapies and vaccines against coronavirus disease 2019 (COVID-19). One major challenge in achieving these goals is the paucity of suitable preclinical animal models. Mice constitute ~70% of all the laboratory animal species used in biomedical research. Unfortunately, SARS-CoV-2 infects mice only if they have been genetically modified to express human ACE2. The inherent resistance of wild-type mice to SARS-CoV-2, combined with a wealth of genetic tools that are available only for modifying mice, offers a unique opportunity to create a versatile set of genetically engineered mouse models useful for COVID-19 research. We propose three broad categories of these models and more than two dozen designs that may be useful for SARS-CoV-2 research and for fighting COVID-19. |*Disease Models, Animal[MESH] |Angiotensin-Converting Enzyme 2/genetics[MESH] |Animals[MESH] |Base Sequence[MESH] |COVID-19/*genetics[MESH] |Gene Knock-In Techniques[MESH] |Genetic Engineering[MESH] |Genetic Loci/genetics[MESH] |Mice[MESH] |Mice, Transgenic[MESH]Genetically modified mouse models to help fight COVID-19 (epmc).pdf DeepDyve Pubget Overpricing