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10.1038/s41598-020-74050-8 http://scihub22266oqcxt.onion/10.1038/s41598-020-74050-8 33106569!7588421!33106569     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 18289 Nephropedia Template TP {{tp|p=33106569|t=2020. The global population of SARS-CoV-2 is composed of six major subtypes |pdf=|usr=}}{{33106569}} gab.com Text The global population of SARS-CoV-2 is composed of six major subtypes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33106569 #FOAvip The World Health Organization characterized COVID-19 as a pandemic in March 2020, the second pandemic of the twenty-first century. Expanding virus populations, such as that of SARS-CoV-2, accumulate a number of narrowly shared polymorphisms, imposing a confounding effect on traditional clustering methods. In this context, approaches that reduce the complexity of the sequence space occupied by the SARS-CoV-2 population are necessary for robust clustering. Here, we propose subdividing the global SARS-CoV-2 population into six well-defined subtypes and 10 poorly represented genotypes named tentative subtypes by focusing on the widely shared polymorphisms in nonstructural (nsp3, nsp4, nsp6, nsp12, nsp13 and nsp14) cistrons and structural (spike and nucleocapsid) and accessory (ORF8) genes. The six subtypes and the additional genotypes showed amino acid replacements that might have phenotypic implications. Notably, three mutations (one of them in the Spike protein) were responsible for the geographical segregation of subtypes. We hypothesize that the virus subtypes detected in this study are records of the early stages of SARS-CoV-2 diversification that were randomly sampled to compose the virus populations around the world. The genetic structure determined for the SARS-CoV-2 population provides substantial guidelines for maximizing the effectiveness of trials for testing candidate vaccines or drugs. Twit Text FOAVip The global population of SARS-CoV-2 is composed of six major subtypes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33106569 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33106569 #FOAvip English Wikipedia <ref>{{Cite pmid|33106569}}</ref> The global population of SARS-CoV-2 is composed of six major subtypes #MMPMID33106569 Morais IJ; Polveiro RC; Souza GM; Bortolin DI; Sassaki FT; Lima ATM Sci Rep 2020[Oct]; 10 (1): 18289 PMID33106569show ga The World Health Organization characterized COVID-19 as a pandemic in March 2020, the second pandemic of the twenty-first century. Expanding virus populations, such as that of SARS-CoV-2, accumulate a number of narrowly shared polymorphisms, imposing a confounding effect on traditional clustering methods. In this context, approaches that reduce the complexity of the sequence space occupied by the SARS-CoV-2 population are necessary for robust clustering. Here, we propose subdividing the global SARS-CoV-2 population into six well-defined subtypes and 10 poorly represented genotypes named tentative subtypes by focusing on the widely shared polymorphisms in nonstructural (nsp3, nsp4, nsp6, nsp12, nsp13 and nsp14) cistrons and structural (spike and nucleocapsid) and accessory (ORF8) genes. The six subtypes and the additional genotypes showed amino acid replacements that might have phenotypic implications. Notably, three mutations (one of them in the Spike protein) were responsible for the geographical segregation of subtypes. We hypothesize that the virus subtypes detected in this study are records of the early stages of SARS-CoV-2 diversification that were randomly sampled to compose the virus populations around the world. The genetic structure determined for the SARS-CoV-2 population provides substantial guidelines for maximizing the effectiveness of trials for testing candidate vaccines or drugs. |*Polymorphism, Genetic[MESH] |Betacoronavirus/classification/*genetics/isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology/pathology/virology[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |Genotype[MESH] |Humans[MESH] |Nucleocapsid Proteins/genetics[MESH] |Pandemics[MESH] |Phosphoproteins[MESH] |Phylogeny[MESH] |Pneumonia, Viral/epidemiology/pathology/virology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH] |Viral Nonstructural Proteins/genetics[MESH]The global population of SARS-CoV-2 is composed of six major subtypes (epmc).pdf DeepDyve Pubget Overpricing