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10.1038/s41467-020-19167-0 http://scihub22266oqcxt.onion/10.1038/s41467-020-19167-0 33106488!7588412!33106488     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 5386 Nephropedia Template TP {{tp|p=33106488|t=2020. Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat |pdf=|usr=}}{{33106488}} gab.com Text Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33106488 #FOAvip Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex (sgACC/25) has been implicated in these illnesses, it is unknown whether this over-activity is causal. By combining targeted intracerebral microinfusions with cardiovascular and behavioral monitoring in marmosets, we show that over-activation of sgACC/25 reduces vagal tone and heart rate variability, alters cortisol dynamics during stress and heightens reactivity to proximal and distal threat. (18)F-FDG PET imaging shows these changes are accompanied by altered activity within a network of brain regions including the amygdala, hypothalamus and dorsolateral prefrontal cortex. Ketamine, shown to have rapid antidepressant effects, fails to reverse elevated arousal to distal threat contrary to the beneficial effects we have previously demonstrated on over-activation induced reward blunting, illustrating the symptom-specificity of its actions. Twit Text FOAVip Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33106488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33106488 #FOAvip English Wikipedia <ref>{{Cite pmid|33106488}}</ref> Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat #MMPMID33106488 Alexander L; Wood CM; Gaskin PLR; Sawiak SJ; Fryer TD; Hong YT; McIver L; Clarke HF; Roberts AC Nat Commun 2020[Oct]; 11 (1): 5386 PMID33106488show ga Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex (sgACC/25) has been implicated in these illnesses, it is unknown whether this over-activity is causal. By combining targeted intracerebral microinfusions with cardiovascular and behavioral monitoring in marmosets, we show that over-activation of sgACC/25 reduces vagal tone and heart rate variability, alters cortisol dynamics during stress and heightens reactivity to proximal and distal threat. (18)F-FDG PET imaging shows these changes are accompanied by altered activity within a network of brain regions including the amygdala, hypothalamus and dorsolateral prefrontal cortex. Ketamine, shown to have rapid antidepressant effects, fails to reverse elevated arousal to distal threat contrary to the beneficial effects we have previously demonstrated on over-activation induced reward blunting, illustrating the symptom-specificity of its actions. |*Cardiovascular Physiological Phenomena[MESH] |Animals[MESH] |Arousal[MESH] |Autonomic Pathways/*physiology[MESH] |Behavior, Animal[MESH] |Callithrix/physiology/*psychology[MESH] |Fear[MESH] |Female[MESH] |Gyrus Cinguli/diagnostic imaging/*physiology[MESH] |Heart Rate[MESH] |Hydrocortisone/metabolism[MESH] |Male[MESH]Over-activation of primate subgenual cingulate cortex enhances the ca(epmc).pdf DeepDyve Pubget Overpricing