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10.1016/j.isci.2020.101697 http://scihub22266oqcxt.onion/10.1016/j.isci.2020.101697 33103068!7571421!33103068     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2020 ; 23 (11): 101697 Nephropedia Template TP {{tp|p=33103068|t=2020. Integrative Transcriptome Analyses Empower the Anti-COVID-19 Drug Arsenal |pdf=|usr=}}{{33103068}} gab.com Text Integrative Transcriptome Analyses Empower the Anti-COVID-19 Drug Arsenal JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=33103068 #FOAvip The beginning of the 21st century has been marked by three distinct waves of zoonotic coronavirus outbreaks into the human population. The COVID-19 (coronavirus disease 2019) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and emerged as a global threat endangering the livelihoods of millions worldwide. Currently, and despite collaborative efforts, diverse therapeutic strategies from ongoing clinical trials are still debated. To address the need for such an immediate call of action, we leveraged the largest dataset of drug-induced transcriptomic perturbations, public SARS-CoV-2 transcriptomic datasets, and expression profiles from normal lung transcriptomes. Most importantly, our unbiased systems biology approach prioritized more than 50 repurposable drug candidates (e.g., corticosteroids, Janus kinase and Bruton kinase inhibitors). Further clinical investigation of these FDA-approved candidates as monotherapy or in combination with an antiviral regimen (e.g., remdesivir) could lead to promising outcomes in patients with COVID-19. Twit Text FOAVip Integrative Transcriptome Analyses Empower the Anti-COVID-19 Drug Arsenal ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=33103068 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33103068 #FOAvip English Wikipedia <ref>{{Cite pmid|33103068}}</ref> Integrative Transcriptome Analyses Empower the Anti-COVID-19 Drug Arsenal #MMPMID33103068 El-Hachem N; Eid E; Nemer G; Dbaibo G; Abbas O; Rubeiz N; Zeineldine S; Matar GM; Bikorimana JP; Shammaa R; Haibe-Kains B; Kurban M; Rafei M iScience 2020[Nov]; 23 (11): 101697 PMID33103068show ga The beginning of the 21st century has been marked by three distinct waves of zoonotic coronavirus outbreaks into the human population. The COVID-19 (coronavirus disease 2019) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and emerged as a global threat endangering the livelihoods of millions worldwide. Currently, and despite collaborative efforts, diverse therapeutic strategies from ongoing clinical trials are still debated. To address the need for such an immediate call of action, we leveraged the largest dataset of drug-induced transcriptomic perturbations, public SARS-CoV-2 transcriptomic datasets, and expression profiles from normal lung transcriptomes. Most importantly, our unbiased systems biology approach prioritized more than 50 repurposable drug candidates (e.g., corticosteroids, Janus kinase and Bruton kinase inhibitors). Further clinical investigation of these FDA-approved candidates as monotherapy or in combination with an antiviral regimen (e.g., remdesivir) could lead to promising outcomes in patients with COVID-19. äIntegrative Transcriptome Analyses Empower the Anti-COVID-19 Drug Arse(epmc).pdf DeepDyve Pubget Overpricing