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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 JACC+Basic+Transl+Sci 2021 ; 6 (1): 1-8 Nephropedia Template TP
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The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection #MMPMID33102950
Beddingfield BJ; Iwanaga N; Chapagain PP; Zheng W; Roy CJ; Hu TY; Kolls JK; Bix GJ
JACC Basic Transl Sci 2021[Jan]; 6 (1): 1-8 PMID33102950show ga
Many efforts to design and screen therapeutics for the current severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry by disrupting angiotensin-converting enzyme-2 (ACE2) binding with the SARS-CoV-2 spike protein. This work focuses on the potential to inhibit SARS-CoV-2 entry through a hypothesized alpha5beta1 integrin-based mechanism and indicates that inhibiting the spike protein interaction with alpha5beta1 integrin (+/- ACE2) and the interaction between alpha5beta1 integrin and ACE2 using a novel molecule (ATN-161) represents a promising approach to treat coronavirus disease-19.