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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Genet 2020 ; 11 (ä): 564741 Nephropedia Template TP
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Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution in India #MMPMID33101387
Srivastava A; Bandopadhyay A; Das D; Pandey RK; Singh V; Khanam N; Srivastava N; Singh PP; Dubey PK; Pathak A; Gupta P; Rai N; Sultana GNN; Chaubey G
Front Genet 2020[]; 11 (ä): 564741 PMID33101387show ga
Studies on host-pathogen interaction have identified human ACE2 as a host cell receptor responsible for mediating infection by coronavirus (COVID-19). Subsequent studies have shown striking difference of allele frequency among Europeans and Asians for a polymorphism rs2285666, present in ACE2. It has been revealed that the alternate allele (TT-plus strand or AA-minus strand) of rs2285666 elevate the expression level of this gene upto 50%, hence may play a significant role in SARS-CoV-2 susceptibility. Therefore, we have first looked the phylogenetic structure of rs2285666 derived haplotypes in worldwide populations and compared the spatial frequency of this particular allele with respect to the COVID-19 infection as well as case-fatality rate in India. For the first time, we ascertained a significant positive correlation for alternate allele (T or A) of rs2285666, with the lower infection as well as case-fatality rate among Indian populations. We trust that this information will be useful to understand the role of ACE2 in COVID-19 susceptibility.