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10.1017/S0950268820002599 http://scihub22266oqcxt.onion/10.1017/S0950268820002599 33100263!7653495!33100263     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epidemiol+Infect 2020 ; 148 (ä): e262 Nephropedia Template TP {{tp|p=33100263|t=2020. ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection |pdf=|usr=}}{{33100263}} gab.com Text ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection JO: Epidemiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33100263 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently caused acute respiratory distress syndrome affecting more than 200 countries with varied mortality rate. Successive genetic variants of SARS-CoV-2 become evident across the globe immediately after its complete genome sequencing. Here, we found a decent association of SARS-CoV-2 ORF3a mutation with higher mortality rate. Extensive in silico studies revealed several amino acid changes in ORF3a protein which ultimately leads to diverse structural modifications like B cell epitope loss, gain/loss of phosphorylation site and loss of leucine zipper motif. We could further relate these changes to the enhanced antigenic diversity of SARS-CoV-2. Through protein-protein network analysis and functional annotation studies, we obtained a close federation of ORF3a protein with host immune response via divergent signal transduction pathways including JAK-STAT, chemokine and cytokine-related pathways. Our data not only unveil the fairly appreciable association of ORF3a mutation with higher mortality rate, but also suggest a potential mechanistic insight towards the immunopathogenic manifestation of SARS-CoV-2 infection. Twit Text FOAVip ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection ????Epidemiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33100263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33100263 #FOAvip English Wikipedia <ref>{{Cite pmid|33100263}}</ref> ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection #MMPMID33100263 Majumdar P; Niyogi S Epidemiol Infect 2020[Oct]; 148 (ä): e262 PMID33100263show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently caused acute respiratory distress syndrome affecting more than 200 countries with varied mortality rate. Successive genetic variants of SARS-CoV-2 become evident across the globe immediately after its complete genome sequencing. Here, we found a decent association of SARS-CoV-2 ORF3a mutation with higher mortality rate. Extensive in silico studies revealed several amino acid changes in ORF3a protein which ultimately leads to diverse structural modifications like B cell epitope loss, gain/loss of phosphorylation site and loss of leucine zipper motif. We could further relate these changes to the enhanced antigenic diversity of SARS-CoV-2. Through protein-protein network analysis and functional annotation studies, we obtained a close federation of ORF3a protein with host immune response via divergent signal transduction pathways including JAK-STAT, chemokine and cytokine-related pathways. Our data not only unveil the fairly appreciable association of ORF3a mutation with higher mortality rate, but also suggest a potential mechanistic insight towards the immunopathogenic manifestation of SARS-CoV-2 infection. |Amino Acid Sequence[MESH] |Betacoronavirus/*genetics[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/*mortality[MESH] |Cytokines/immunology[MESH] |Humans[MESH] |Immune Evasion[MESH] |Mutation[MESH] |Mutation Rate[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/*mortality[MESH] |SARS-CoV-2[MESH] |Signal Transduction[MESH] |Viral Regulatory and Accessory Proteins/*genetics[MESH]ORF3a mutation associated with higher mortality rate in SARS-CoV-2 inf(epmc).pdf DeepDyve Pubget Overpricing