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10.1093/jac/dkaa442

http://scihub22266oqcxt.onion/10.1093/jac/dkaa442
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33099620!7665528!33099620
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suck abstract from ncbi


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pmid33099620      J+Antimicrob+Chemother 2021 ; 76 (2): 283-285
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  • Treating COVID-19: are we missing out the window of opportunity? #MMPMID33099620
  • Sundararaj Stanleyraj J; Sethuraman N; Gupta R; Thiruvoth S; Gupta M; Ryo A
  • J Antimicrob Chemother 2021[Jan]; 76 (2): 283-285 PMID33099620show ga
  • Severe COVID-19 is a biphasic illness, with an initial viral replication phase, followed by a cascade of inflammatory events. Progression to severe disease is predominantly a function of the inflammatory cascade, rather than viral replication per se. This understanding can be effectively translated to changing our approach in managing the disease. The natural course of disease offers us separate windows of specific time intervals to administer either antiviral or immunomodulatory therapy. Instituting the right attack at the right time would maximize the benefit of treatment. This concept must also be factored into studies that assess the efficacy of antivirals and immunomodulatory agents against COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Time-to-Treatment[MESH]
  • |Antiviral Agents/*administration & dosage/therapeutic use[MESH]
  • |COVID-19/immunology/virology[MESH]
  • |Cytokines/blood[MESH]
  • |Disease Progression[MESH]
  • |Humans[MESH]
  • |Immunomodulation/*drug effects/immunology[MESH]
  • |Immunosuppressive Agents/*administration & dosage/therapeutic use[MESH]
  • |SARS-CoV-2/drug effects[MESH]


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