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Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19) #MMPMID33099028
Lopez-Mendez I; Aquino-Matus J; Gall SM; Prieto-Nava JD; Juarez-Hernandez E; Uribe M; Castro-Narro G
Ann Hepatol 2021[Jan]; 20 (?): 100271 PMID33099028show ga
INTRODUCTION AND OBJECTIVES: Liver function tests (LFT) abnormalities are reported in up to 50% of COVID-19 patients, and metabolic comorbidities are associated with poorer outcomes. The aim of the study was to determine the prevalence of liver steatosis and fibrosis in patients with COVID-19 and their association with clinical outcomes. MATERIAL AND METHODS: Retrospective study in hospitalized COVID-19 patients was conducted. The risk for liver steatosis was estimated by HSI > 36, and risk for advanced liver fibrosis with APRI > 1.0, NAFLD FS > 0.675 and/or FIB-4 > 3.25. Clinical outcomes were admission to Intensive Care Unit (ICU) and mortality. RESULTS: Of 155 patients, 71.6% were male (n = 111), and 28.4% (n = 44) were obese. Abnormal LFT were present in 96.8% (n = 150), prevalence of steatosis was 42.6% (n = 66) and of significative liver fibrosis was 44.5% (n = 69). Liver fibrosis by FIB-4 was associated with risk of ICU admission (OR 1.74 [95%CI 1.74-2.68; p = 0.023]) and mortality (OR 6.45 [95%CI 2.01-20.83, p = 0.002]); no independent associations were found. CONCLUSIONS: The prevalence of steatosis and significant liver fibrosis was high in COVID-19 patients but was not associated with clinical outcomes.
|Adult[MESH]
|Alanine Transaminase/blood[MESH]
|Aspartate Aminotransferases/blood[MESH]
|Biomarkers/blood[MESH]
|COVID-19/*epidemiology[MESH]
|Comorbidity[MESH]
|Cross-Sectional Studies[MESH]
|Female[MESH]
|Follow-Up Studies[MESH]
|Humans[MESH]
|Intensive Care Units/*statistics & numerical data[MESH]