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10.1016/j.cbi.2020.109300 http://scihub22266oqcxt.onion/10.1016/j.cbi.2020.109300 33098838!7577920!33098838     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Biol+Interact 2021 ; 334 (ä): 109300 Nephropedia Template TP {{tp|p=33098838|t=2021. Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo c phenanthridine and berberine-based compounds on beta-amyloid aggregation |pdf=|usr=}}{{33098838}} gab.com Text Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo c phenanthridine and berberine-based compounds on beta-amyloid aggregation JO: Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=33098838 #FOAvip Herein we present a comparative study of the effects of isoquinoline alkaloids belonging to benzo[c]phenanthridine and berberine families on beta-amyloid aggregation. Results obtained using a Thioflavine T (ThT) fluorescence assay and circular dichroism (CD) spectroscopy suggested that the benzo[c]phenanthridine nucleus, present in both sanguinarine and chelerythrine molecules, was directly involved in an inhibitory effect of Abeta(1-42) aggregation. Conversely, coralyne, that contains the isomeric berberine nucleus, significantly increased propensity for Abeta(1-42) to aggregate. Surface Plasmon Resonance (SPR) experiments provided quantitative estimation of these interactions: coralyne bound to Abeta(1-42) with an affinity (K(D)?=?11.6?muM) higher than benzo[c]phenanthridines. Molecular docking studies confirmed that all three compounds are able to recognize Abeta(1-42) in different aggregation forms suggesting their effective capacity to modulate the Abeta(1-42) self-recognition mechanism. Molecular dynamics simulations indicated that coralyne increased the beta-content of Abeta(1-42), in early stages of aggregation, consistent with fluorescence-based promotion of the Abeta(1-42) self-recognition mechanism by this alkaloid. At the same time, sanguinarine induced Abeta(1-42) helical conformation corroborating its ability to delay aggregation as experimentally proved in vitro. The investigated compounds were shown to interfere with aggregation of Abeta(1-42) demonstrating their potential as starting leads for the development of therapeutic strategies in neurodegenerative diseases. Twit Text FOAVip Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo c phenanthridine and berberine-based compounds on beta-amyloid aggregation ????Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=33098838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33098838 #FOAvip English Wikipedia <ref>{{Cite pmid|33098838}}</ref> Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo c phenanthridine and berberine-based compounds on beta-amyloid aggregation #MMPMID33098838 Marasco D; Vicidomini C; Krupa P; Cioffi F; Huy PDQ; Li MS; Florio D; Broersen K; De Pandis MF; Roviello GN Chem Biol Interact 2021[Jan]; 334 (ä): 109300 PMID33098838show ga Herein we present a comparative study of the effects of isoquinoline alkaloids belonging to benzo[c]phenanthridine and berberine families on beta-amyloid aggregation. Results obtained using a Thioflavine T (ThT) fluorescence assay and circular dichroism (CD) spectroscopy suggested that the benzo[c]phenanthridine nucleus, present in both sanguinarine and chelerythrine molecules, was directly involved in an inhibitory effect of Abeta(1-42) aggregation. Conversely, coralyne, that contains the isomeric berberine nucleus, significantly increased propensity for Abeta(1-42) to aggregate. Surface Plasmon Resonance (SPR) experiments provided quantitative estimation of these interactions: coralyne bound to Abeta(1-42) with an affinity (K(D)?=?11.6?muM) higher than benzo[c]phenanthridines. Molecular docking studies confirmed that all three compounds are able to recognize Abeta(1-42) in different aggregation forms suggesting their effective capacity to modulate the Abeta(1-42) self-recognition mechanism. Molecular dynamics simulations indicated that coralyne increased the beta-content of Abeta(1-42), in early stages of aggregation, consistent with fluorescence-based promotion of the Abeta(1-42) self-recognition mechanism by this alkaloid. At the same time, sanguinarine induced Abeta(1-42) helical conformation corroborating its ability to delay aggregation as experimentally proved in vitro. The investigated compounds were shown to interfere with aggregation of Abeta(1-42) demonstrating their potential as starting leads for the development of therapeutic strategies in neurodegenerative diseases. |Alkaloids/*pharmacology[MESH] |Amyloid beta-Peptides/*metabolism[MESH] |Benzophenanthridines/pharmacology[MESH] |Berberine Alkaloids/pharmacology[MESH] |Berberine/*pharmacology[MESH] |Humans[MESH] |Isoquinolines/*pharmacology[MESH] |Molecular Docking Simulation[MESH] |Neuroprotective Agents/*pharmacology[MESH] |Phenanthridines/*pharmacology[MESH] |Plants/*chemistry[MESH]Plant isoquinoline alkaloids as potential neurodrugs: A comparative st(epmc).pdf DeepDyve Pubget Overpricing