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10.1007/s10930-020-09933-w http://scihub22266oqcxt.onion/10.1007/s10930-020-09933-w 33098476!7584483!33098476     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Protein+J 2020 ; 39 (6): 600-618 Nephropedia Template TP {{tp|p=33098476|t=2020. An Overview of the Crystallized Structures of the SARS-CoV-2 |pdf=|usr=}}{{33098476}} gab.com Text An Overview of the Crystallized Structures of the SARS-CoV-2 JO: Protein J http://www.kidney.de/pget.php?&tw=1&pmid=33098476 #FOAvip Many research teams all over the world focus their research on the SARS-CoV-2, the new coronavirus that causes the so-called COVID-19 disease. Most of the studies identify the main protease or 3C-like protease (M(pro)/3CL(pro)) as a valid target for large-spectrum inhibitors. Also, the interaction of the human receptor angiotensin-converting enzyme 2 (ACE2) with the viral surface glycoprotein (S) is studied in depth. Structural studies tried to identify the residues responsible for enhancement/weaken virus-ACE2 interactions or the cross-reactivity of the neutralizing antibodies. Although the understanding of the immune system and the hyper-inflammatory process in COVID-19 are crucial for managing the immediate and the long-term consequences of the disease, not many X-ray/NMR/cryo-EM crystals are available. In addition to 3CL(pro), the crystal structures of other nonstructural proteins offer valuable information for elucidating some aspects of the SARS-CoV-2 infection. Thus, the structural analysis of the SARS-CoV-2 is currently mainly focused on three directions-finding M(pro)/3CL(pro) inhibitors, the virus-host cell invasion, and the virus-neutralizing antibody interaction. Twit Text FOAVip An Overview of the Crystallized Structures of the SARS-CoV-2 ????Protein J http://www.kidney.de/pget.php?&tw=1&pmid=33098476 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33098476 #FOAvip English Wikipedia <ref>{{Cite pmid|33098476}}</ref> An Overview of the Crystallized Structures of the SARS-CoV-2 #MMPMID33098476 Ionescu MI Protein J 2020[Dec]; 39 (6): 600-618 PMID33098476show ga Many research teams all over the world focus their research on the SARS-CoV-2, the new coronavirus that causes the so-called COVID-19 disease. Most of the studies identify the main protease or 3C-like protease (M(pro)/3CL(pro)) as a valid target for large-spectrum inhibitors. Also, the interaction of the human receptor angiotensin-converting enzyme 2 (ACE2) with the viral surface glycoprotein (S) is studied in depth. Structural studies tried to identify the residues responsible for enhancement/weaken virus-ACE2 interactions or the cross-reactivity of the neutralizing antibodies. Although the understanding of the immune system and the hyper-inflammatory process in COVID-19 are crucial for managing the immediate and the long-term consequences of the disease, not many X-ray/NMR/cryo-EM crystals are available. In addition to 3CL(pro), the crystal structures of other nonstructural proteins offer valuable information for elucidating some aspects of the SARS-CoV-2 infection. Thus, the structural analysis of the SARS-CoV-2 is currently mainly focused on three directions-finding M(pro)/3CL(pro) inhibitors, the virus-host cell invasion, and the virus-neutralizing antibody interaction. |Amino Acid Sequence[MESH] |Antiviral Agents/pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*virology[MESH] |Coronavirus 3C Proteases/antagonists & inhibitors/*chemistry[MESH] |Coronavirus Nucleocapsid Proteins/antagonists & inhibitors/*chemistry[MESH] |Coronavirus Papain-Like Proteases/antagonists & inhibitors/*chemistry[MESH] |Coronavirus RNA-Dependent RNA Polymerase/antagonists & inhibitors/*chemistry[MESH] |Cryoelectron Microscopy[MESH] |Crystallography, X-Ray[MESH] |Drug Discovery[MESH] |Humans[MESH] |Models, Molecular[MESH] |Nuclear Magnetic Resonance, Biomolecular[MESH] |Phosphoproteins/antagonists & inhibitors/chemistry[MESH] |Protein Conformation[MESH] |Protein Kinase Inhibitors/pharmacology[MESH]An Overview of the Crystallized Structures of the SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing