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10.1038/s42003-020-01343-z http://scihub22266oqcxt.onion/10.1038/s42003-020-01343-z 33097786!7584612!33097786     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2020 ; 3 (1): 603 Nephropedia Template TP {{tp|p=33097786|t=2020. PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling |pdf=|usr=}}{{33097786}} gab.com Text PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33097786 #FOAvip Protein tyrosine phosphatases are essential modulators of angiogenesis and have been identified as novel therapeutic targets in cancer and anti-angiogenesis. The roles of atypical Phosphatase of Regenerative Liver (PRL) phosphatases in this context remain poorly understood. Here, we investigate the biological function of PRL phosphatases in developmental angiogenesis in the postnatal mouse retina and in cell culture. We show that endothelial cells in the retina express PRL-2 encoded by the Ptp4a2 gene, and that inducible endothelial and global Ptp4a2 mutant mice exhibit defective retinal vascular outgrowth, arteriovenous differentiation, and sprouting angiogenesis. Mechanistically, PTP4A2 deletion limits angiogenesis by inhibiting endothelial cell migration and the VEGF-A, DLL-4/NOTCH-1 signaling pathway. This study reveals the importance of PRL-2 as a modulator of vascular development. Twit Text FOAVip PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33097786 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33097786 #FOAvip English Wikipedia <ref>{{Cite pmid|33097786}}</ref> PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling #MMPMID33097786 Poulet M; Sirois J; Boye K; Uetani N; Hardy S; Daubon T; Dubrac A; Tremblay ML; Bikfalvi A Commun Biol 2020[Oct]; 3 (1): 603 PMID33097786show ga Protein tyrosine phosphatases are essential modulators of angiogenesis and have been identified as novel therapeutic targets in cancer and anti-angiogenesis. The roles of atypical Phosphatase of Regenerative Liver (PRL) phosphatases in this context remain poorly understood. Here, we investigate the biological function of PRL phosphatases in developmental angiogenesis in the postnatal mouse retina and in cell culture. We show that endothelial cells in the retina express PRL-2 encoded by the Ptp4a2 gene, and that inducible endothelial and global Ptp4a2 mutant mice exhibit defective retinal vascular outgrowth, arteriovenous differentiation, and sprouting angiogenesis. Mechanistically, PTP4A2 deletion limits angiogenesis by inhibiting endothelial cell migration and the VEGF-A, DLL-4/NOTCH-1 signaling pathway. This study reveals the importance of PRL-2 as a modulator of vascular development. |*Immediate-Early Proteins/genetics/metabolism/physiology[MESH] |*Protein Tyrosine Phosphatases/genetics/metabolism/physiology[MESH] |Animals[MESH] |Cell Movement/genetics[MESH] |Cells, Cultured[MESH] |Endothelial Cells/cytology[MESH] |Female[MESH] |Human Umbilical Vein Endothelial Cells[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Neovascularization, Physiologic/*genetics[MESH] |Retina/cytology/metabolism[MESH] |Signal Transduction/*genetics[MESH]PRL-2 phosphatase is required for vascular morphogenesis and angiogeni(epmc).pdf DeepDyve Pubget Overpricing