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10.1016/j.jclinepi.2020.10.010

http://scihub22266oqcxt.onion/10.1016/j.jclinepi.2020.10.010
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33096223!7575422!33096223
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suck abstract from ncbi


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pmid33096223      J+Clin+Epidemiol 2021 ; 130 (ä): 107-116
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  • Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials #MMPMID33096223
  • Nguyen VT; Riviere P; Ripoll P; Barnier J; Vuillemot R; Ferrand G; Cohen-Boulakia S; Ravaud P; Boutron I
  • J Clin Epidemiol 2021[Feb]; 130 (ä): 107-116 PMID33096223show ga
  • OBJECTIVES: Researchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against coronavirus disease 2019 (COVID-19). Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated. STUDY DESIGN AND SETTING: We performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered. RESULTS: By August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1-Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33-67]; 15-163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 postacute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients. CONCLUSION: This living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic has passed.
  • |*COVID-19 Drug Treatment[MESH]
  • |COVID-19/prevention & control[MESH]
  • |Epidemiologic Research Design[MESH]
  • |Female[MESH]
  • |Geographic Mapping[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*therapeutic use[MESH]
  • |Internet[MESH]
  • |Italy[MESH]
  • |Male[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Randomized Controlled Trials as Topic[MESH]
  • |Sample Size[MESH]


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