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10.1016/j.cell.2020.10.001 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.10.001 33096020!7534589!33096020     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (5): 1340-1353.e16 Nephropedia Template TP {{tp|p=33096020|t=2020. Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4(+) T Cells in COVID-19 |pdf=|usr=}}{{33096020}} gab.com Text Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4(+) T Cells in COVID-19 JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33096020 #FOAvip The contribution of CD4(+) T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4(+) T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, we found increased proportions of cytotoxic follicular helper cells and cytotoxic T helper (T(H)) cells (CD4-CTLs) responding to SARS-CoV-2 and reduced proportion of SARS-CoV-2-reactive regulatory T cells (T(REG)). Importantly, in hospitalized COVID-19 patients, a strong cytotoxic T(FH) response was observed early in the illness, which correlated negatively with antibody levels to SARS-CoV-2 spike protein. Polyfunctional T(H)1 and T(H)17 cell subsets were underrepresented in the repertoire of SARS-CoV-2-reactive CD4(+) T cells compared to influenza-reactive CD4(+) T cells. Together, our analyses provide insights into the gene expression patterns of SARS-CoV-2-reactive CD4(+) T cells in distinct disease severities. Twit Text FOAVip Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4(+) T Cells in COVID-19 ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33096020 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33096020 #FOAvip English Wikipedia <ref>{{Cite pmid|33096020}}</ref> Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4(+) T Cells in COVID-19 #MMPMID33096020 Meckiff BJ; Ramirez-Suastegui C; Fajardo V; Chee SJ; Kusnadi A; Simon H; Eschweiler S; Grifoni A; Pelosi E; Weiskopf D; Sette A; Ay F; Seumois G; Ottensmeier CH; Vijayanand P Cell 2020[Nov]; 183 (5): 1340-1353.e16 PMID33096020show ga The contribution of CD4(+) T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4(+) T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, we found increased proportions of cytotoxic follicular helper cells and cytotoxic T helper (T(H)) cells (CD4-CTLs) responding to SARS-CoV-2 and reduced proportion of SARS-CoV-2-reactive regulatory T cells (T(REG)). Importantly, in hospitalized COVID-19 patients, a strong cytotoxic T(FH) response was observed early in the illness, which correlated negatively with antibody levels to SARS-CoV-2 spike protein. Polyfunctional T(H)1 and T(H)17 cell subsets were underrepresented in the repertoire of SARS-CoV-2-reactive CD4(+) T cells compared to influenza-reactive CD4(+) T cells. Together, our analyses provide insights into the gene expression patterns of SARS-CoV-2-reactive CD4(+) T cells in distinct disease severities. |*Transcriptome[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/blood/immunology[MESH] |CD4 Lymphocyte Count[MESH] |COVID-19/epidemiology/*immunology/virology[MESH] |Cohort Studies[MESH] |England/epidemiology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |SARS-CoV-2/*genetics[MESH] |Severity of Illness Index[MESH] |Single-Cell Analysis/methods[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH] |T Follicular Helper Cells/*immunology[MESH] |T-Lymphocytes, Cytotoxic/*immunology[MESH]Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4(+) T Cel(epmc).pdf DeepDyve Pubget Overpricing