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10.1002/jbt.22656 http://scihub22266oqcxt.onion/10.1002/jbt.22656 33094891!7645950!33094891     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biochem+Mol+Toxicol 2021 ; 35 (3): e22656 Nephropedia Template TP {{tp|p=33094891|t=2021. Discovery of novel pyrazole derivatives as a potent anti-inflammatory agent in RAW264 7 cells via inhibition of NF-kB for possible benefit against SARS-CoV-2 |pdf=|usr=}}{{33094891}} gab.com Text Discovery of novel pyrazole derivatives as a potent anti-inflammatory agent in RAW264 7 cells via inhibition of NF-kB for possible benefit against SARS-CoV-2 JO: J Biochem Mol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=33094891 #FOAvip Due to unavailability of a specific drug/vaccine to attenuate severe acute respiratory syndrome coronavirus 2, the current strategy to combat the infection has been largely dependent upon the use of anti-inflammatory drugs to control cytokines storm responsible for respiratory depression. Thus, in this study, we discovered novel pyrazole analogs as a potent nuclear factor kappa B (NF-kB) inhibitor. The compounds were assessed for NF-kB transcriptional inhibitory activity in RAW264.7 cells after stimulation with lipopolysaccharides (LPS), revealing Compound 6c as the most potent analog among the tested series. The effect of Compound 6c was further investigated on the levels of interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 in LPS-stimulated RAW267.4 cells by enzyme immunoassay, where it causes a significant reduction in the level of these cytokines. In Western blot analysis, Compound 6c also causes the inhibition of inhibitor kappa B-alpha and NF-kappaB. It was found to be snugly fitted into the inner grove of the active site of NF-kB by forming H-bonds and a nonbonded interaction with Asn28 in a docking analysis. Twit Text FOAVip Discovery of novel pyrazole derivatives as a potent anti-inflammatory agent in RAW264 7 cells via inhibition of NF-kB for possible benefit against SARS-CoV-2 ????J Biochem Mol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=33094891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33094891 #FOAvip English Wikipedia <ref>{{Cite pmid|33094891}}</ref> Discovery of novel pyrazole derivatives as a potent anti-inflammatory agent in RAW264 7 cells via inhibition of NF-kB for possible benefit against SARS-CoV-2 #MMPMID33094891 Masih A; Agnihotri AK; Srivastava JK; Pandey N; Bhat HR; Singh UP J Biochem Mol Toxicol 2021[Mar]; 35 (3): e22656 PMID33094891show ga Due to unavailability of a specific drug/vaccine to attenuate severe acute respiratory syndrome coronavirus 2, the current strategy to combat the infection has been largely dependent upon the use of anti-inflammatory drugs to control cytokines storm responsible for respiratory depression. Thus, in this study, we discovered novel pyrazole analogs as a potent nuclear factor kappa B (NF-kB) inhibitor. The compounds were assessed for NF-kB transcriptional inhibitory activity in RAW264.7 cells after stimulation with lipopolysaccharides (LPS), revealing Compound 6c as the most potent analog among the tested series. The effect of Compound 6c was further investigated on the levels of interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 in LPS-stimulated RAW267.4 cells by enzyme immunoassay, where it causes a significant reduction in the level of these cytokines. In Western blot analysis, Compound 6c also causes the inhibition of inhibitor kappa B-alpha and NF-kappaB. It was found to be snugly fitted into the inner grove of the active site of NF-kB by forming H-bonds and a nonbonded interaction with Asn28 in a docking analysis. |*Anti-Inflammatory Agents/chemistry/pharmacology[MESH] |*COVID-19 Drug Treatment[MESH] |*COVID-19/metabolism/pathology[MESH] |*Molecular Docking Simulation[MESH] |*NF-KappaB Inhibitor alpha/antagonists & inhibitors/chemistry/metabolism[MESH] |*Pyrazoles/chemistry/pharmacology[MESH] |Animals[MESH] |Cytokines/metabolism[MESH] |Mice[MESH] |NF-kappa B/*metabolism[MESH] |RAW 264.7 Cells[MESH] |SARS-CoV-2/*metabolism[MESH]Discovery of novel pyrazole derivatives as a potent anti-inflammatory (epmc).pdf DeepDyve Pubget Overpricing