Zinc and COVID-19: Basis of Current Clinical Trials #MMPMID33094446
Pal A; Squitti R; Picozza M; Pawar A; Rongioletti M; Dutta AK; Sahoo S; Goswami K; Sharma P; Prasad R
Biol Trace Elem Res 2021[Aug]; 199 (8): 2882-2892 PMID33094446show ga
Coronavirus disease-2019 (COVID-19) pandemic continues to threaten patients, societies, and economic and healthcare systems around the world. Like many other diseases, the host immune system determines the progress of COVID-19 and fatality. Modulation of inflammatory response and cytokine production using immunonutrition is a novel concept that has been applied to other diseases as well. Zinc, one of the anti-inflammatory and antioxidant micronutrient found in food with well-established role in immunity, is currently being used in some clinical trials against COVID-19. This review integrates the contemporary studies of role of zinc in antiviral immunity along with discussing its potential role against COVID-19, and ongoing COVID-19 clinical trials using zinc.