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10.1038/s41434-020-00204-y

http://scihub22266oqcxt.onion/10.1038/s41434-020-00204-y
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33093657!7580817!33093657
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suck abstract from ncbi

pmid33093657      Gene+Ther 2021 ; 28 (3-4): 117-129
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  • Self-amplifying RNA vaccines for infectious diseases #MMPMID33093657
  • Bloom K; van den Berg F; Arbuthnot P
  • Gene Ther 2021[Apr]; 28 (3-4): 117-129 PMID33093657show ga
  • Vaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development pipeline is based on in vitro transcription of antigen-encoding sequences or immunotherapies as synthetic RNA transcripts, which are then formulated for delivery. This approach may enable a quicker response to emerging disease outbreaks, as is evident from the swift pursuit of RNA vaccine candidates for the global SARS-CoV-2 pandemic. Both conventional and self-amplifying RNAs have shown protective immunization in preclinical studies against multiple infectious diseases including influenza, RSV, Rabies, Ebola, and HIV-1. Self-amplifying RNAs have shown enhanced antigen expression at lower doses compared to conventional mRNA, suggesting this technology may improve immunization. This review will explore how self-amplifying RNAs are emerging as important vaccine candidates for infectious diseases, the advantages of synthetic manufacturing approaches, and their potential for preventing and treating chronic infections.
  • |*Vaccination[MESH]
  • |COVID-19 Vaccines/genetics/*immunology/therapeutic use[MESH]
  • |COVID-19/epidemiology/genetics/*immunology/*prevention & control[MESH]
  • |Humans[MESH]
  • |RNA, Viral/genetics/*immunology/therapeutic use[MESH]


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