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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (45): 27820-27824 Nephropedia Template TP
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Laser spectroscopic technique for direct identification of a single virus I: FASTER CARS #MMPMID33093197
Deckert V; Deckert-Gaudig T; Cialla-May D; Popp J; Zell R; Deinhard-Emmer S; Sokolov AV; Yi Z; Scully MO
Proc Natl Acad Sci U S A 2020[Nov]; 117 (45): 27820-27824 PMID33093197show ga
From the famous 1918 H1N1 influenza to the present COVID-19 pandemic, the need for improved viral detection techniques is all too apparent. The aim of the present paper is to show that identification of individual virus particles in clinical sample materials quickly and reliably is near at hand. First of all, our team has developed techniques for identification of virions based on a modular atomic force microscopy (AFM). Furthermore, femtosecond adaptive spectroscopic techniques with enhanced resolution via coherent anti-Stokes Raman scattering (FASTER CARS) using tip-enhanced techniques markedly improves the sensitivity [M. O. Scully, et al, Proc. Natl. Acad. Sci. U.S.A. 99, 10994-11001 (2002)].