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10.1016/j.micpath.2020.104586 http://scihub22266oqcxt.onion/10.1016/j.micpath.2020.104586 33091582!7573633!33091582     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33091582&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Microb+Pathog 2020 ; 149 (?): 104586 Nephropedia Template TP {{tp|p=33091582|t=2020. Inhibition of N-linked Glycosylation by Tunicamycin May Contribute to The Treatment of SARS-CoV-2 |pdf=|usr=}}{{33091582}} gab.com Text Inhibition of N-linked Glycosylation by Tunicamycin May Contribute to The Treatment of SARS-CoV-2 JO: Microb Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33091582 #FOAvip SARS-CoV-2 remains a medical and economic challenge, due to the lack of a suitable drug or vaccine. The glycans in some proteins play a pivotal role in protein folding, oligomerization, quality control, sorting, and transport so the hindering of N-linked glycosylation of glycoproteins will prevent assembly of the virion. Tunicamycin an anticancer drug inhibit the N- linked glycans. Our study aimed to find out the mechanism action of tunicamycin on the viral glycoproteins. The growth of coronavirus in the presence inhibitor tunicamycin resulted in the production of spikeless, non-infectious virions which were devoid of S protein. We concluded that tunicamycin inhibits E2, S, and M glycoproteins of coronaviruses. Tunicamycin is also diminished glycosylation of PTMs such as HE, and 8 ab of SARS-CoV. Finally, we recommend using this drug to treat the SARS-CoV-2. Twit Text FOAVip Inhibition of N-linked Glycosylation by Tunicamycin May Contribute to The Treatment of SARS-CoV-2 ????Microb Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33091582 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33091582 #FOAvip English Wikipedia <ref>{{Cite pmid|33091582}}</ref> Inhibition of N-linked Glycosylation by Tunicamycin May Contribute to The Treatment of SARS-CoV-2 #MMPMID33091582 Dawood AA; Altobje MA Microb Pathog 2020[Dec]; 149 (?): 104586 PMID33091582show ga SARS-CoV-2 remains a medical and economic challenge, due to the lack of a suitable drug or vaccine. The glycans in some proteins play a pivotal role in protein folding, oligomerization, quality control, sorting, and transport so the hindering of N-linked glycosylation of glycoproteins will prevent assembly of the virion. Tunicamycin an anticancer drug inhibit the N- linked glycans. Our study aimed to find out the mechanism action of tunicamycin on the viral glycoproteins. The growth of coronavirus in the presence inhibitor tunicamycin resulted in the production of spikeless, non-infectious virions which were devoid of S protein. We concluded that tunicamycin inhibits E2, S, and M glycoproteins of coronaviruses. Tunicamycin is also diminished glycosylation of PTMs such as HE, and 8 ab of SARS-CoV. Finally, we recommend using this drug to treat the SARS-CoV-2. |*COVID-19 Drug Treatment[MESH] |Animals[MESH] |COVID-19/metabolism[MESH] |Glycosylation/drug effects[MESH] |Humans[MESH] |SARS-CoV-2/*drug effects/metabolism[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH] |Tunicamycin/*pharmacology[MESH]Inhibition of N-linked Glycosylation by Tunicamycin May Contribute to (epmc).pdf DeepDyve Pubget Overpricing