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10.1002/jmv.26599 http://scihub22266oqcxt.onion/10.1002/jmv.26599 33090527!7675319!33090527     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33090527&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Med+Virol 2021 ; 93 (4): 2141-2148 Nephropedia Template TP {{tp|p=33090527|t=2021. Early clinical factors predicting the development of critical disease in Japanese patients with COVID-19: A single-center, retrospective, observational study |pdf=|usr=}}{{33090527}} gab.com Text Early clinical factors predicting the development of critical disease in Japanese patients with COVID-19: A single-center, retrospective, observational study JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33090527 #FOAvip The factors predicting the progression of coronavirus disease-2019 (COVID-19) from mild to moderate to critical are unclear. We retrospectively evaluated risk factors for disease progression in Japanese patients with COVID-19. Seventy-four patients with laboratory-confirmed COVID-19 were hospitalized in our hospital between February 20, 2020, and June 10, 2020. We excluded asymptomatic, non-Japanese, and pediatric patients. We divided patients into the stable group and the progression group (PG; requiring mechanical ventilation). We compared the clinical factors. We established the cutoff values (COVs) for significantly different factors via receiver operating characteristic curve analysis and identified risk factors by univariate regression. We enrolled 57 patients with COVID-19 (median age 52 years, 56.1% male). The median time from symptom onset to admission was 8 days. Seven patients developed critical disease (PG: 12.2%), two (3.5%) of whom died; 50 had stable disease. Univariate logistic analysis identified an elevated lactate dehydrogenase (LDH) level (COV: 309 U/l), a decreased estimated glomerular filtration rate (eGFR; COV: 68 ml/min), lymphocytopenia (COV: 980/mul), and statin use as significantly associated with disease progression. However, in the Cox proportional hazards analysis, lymphocytopenia at admission was not significant. We identified three candidate risk factors for progression to critical COVID-19 in adult Japanese patients: statin use, elevated LDH level, and decreased eGFR. Twit Text FOAVip Early clinical factors predicting the development of critical disease in Japanese patients with COVID-19: A single-center, retrospective, observational study ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33090527 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33090527 #FOAvip English Wikipedia <ref>{{Cite pmid|33090527}}</ref> Early clinical factors predicting the development of critical disease in Japanese patients with COVID-19: A single-center, retrospective, observational study #MMPMID33090527 Higuchi T; Nishida T; Iwahashi H; Morimura O; Otani Y; Okauchi Y; Yokoe M; Suzuki N; Inada M; Abe K J Med Virol 2021[Apr]; 93 (4): 2141-2148 PMID33090527show ga The factors predicting the progression of coronavirus disease-2019 (COVID-19) from mild to moderate to critical are unclear. We retrospectively evaluated risk factors for disease progression in Japanese patients with COVID-19. Seventy-four patients with laboratory-confirmed COVID-19 were hospitalized in our hospital between February 20, 2020, and June 10, 2020. We excluded asymptomatic, non-Japanese, and pediatric patients. We divided patients into the stable group and the progression group (PG; requiring mechanical ventilation). We compared the clinical factors. We established the cutoff values (COVs) for significantly different factors via receiver operating characteristic curve analysis and identified risk factors by univariate regression. We enrolled 57 patients with COVID-19 (median age 52 years, 56.1% male). The median time from symptom onset to admission was 8 days. Seven patients developed critical disease (PG: 12.2%), two (3.5%) of whom died; 50 had stable disease. Univariate logistic analysis identified an elevated lactate dehydrogenase (LDH) level (COV: 309 U/l), a decreased estimated glomerular filtration rate (eGFR; COV: 68 ml/min), lymphocytopenia (COV: 980/mul), and statin use as significantly associated with disease progression. However, in the Cox proportional hazards analysis, lymphocytopenia at admission was not significant. We identified three candidate risk factors for progression to critical COVID-19 in adult Japanese patients: statin use, elevated LDH level, and decreased eGFR. |*Critical Illness[MESH] |Adult[MESH] |Aged[MESH] |Biomarkers[MESH] |COVID-19/*diagnosis/epidemiology[MESH] |Disease Progression[MESH] |Female[MESH] |Humans[MESH] |Japan[MESH] |Male[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH]Early clinical factors predicting the development of critical disease (epmc).pdf DeepDyve Pubget Overpricing