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10.1002/jmv.26598 http://scihub22266oqcxt.onion/10.1002/jmv.26598 33090493!7675664!33090493     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (5): 2790-2798 Nephropedia Template TP {{tp|p=33090493|t=2021. Mutations in membrane-fusion subunit of spike glycoprotein play crucial role in the recent outbreak of COVID-19 |pdf=|usr=}}{{33090493}} gab.com Text Mutations in membrane-fusion subunit of spike glycoprotein play crucial role in the recent outbreak of COVID-19 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33090493 #FOAvip Coronavirus disease-2019 (COVID-19), the ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major threat to the entire human race. It is reported that SARS-CoV-2 seems to have relatively low pathogenicity and higher transmissibility than previously outbroke SARS-CoV. To explore the reason of the increased transmissibility of SARS-CoV-2 compared with SARS-CoV, we have performed a comparative analysis on the structural proteins (spike, envelope, membrane, and nucleoprotein) of two viruses. Our analysis revealed that extensive substitutions of hydrophobic to polar and charged amino acids in spike glycoproteins of SARS-CoV2 creates an intrinsically disordered region (IDR) at the beginning of membrane-fusion subunit and intrinsically disordered residues in fusion peptide. IDR provides a potential site for proteolysis by furin and enriched disordered residues facilitate prompt fusion of the SARS-CoV2 with host membrane by recruiting molecular recognition features. Here, we have hypothesized that mutation-driven accumulation of intrinsically disordered residues in spike glycoproteins play dual role in enhancing viral transmissibility than previous SARS-coronavirus. These analyses may help in epidemic surveillance and preventive measures against COVID-19. Twit Text FOAVip Mutations in membrane-fusion subunit of spike glycoprotein play crucial role in the recent outbreak of COVID-19 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33090493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33090493 #FOAvip English Wikipedia <ref>{{Cite pmid|33090493}}</ref> Mutations in membrane-fusion subunit of spike glycoprotein play crucial role in the recent outbreak of COVID-19 #MMPMID33090493 Podder S; Ghosh A; Ghosh T J Med Virol 2021[May]; 93 (5): 2790-2798 PMID33090493show ga Coronavirus disease-2019 (COVID-19), the ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major threat to the entire human race. It is reported that SARS-CoV-2 seems to have relatively low pathogenicity and higher transmissibility than previously outbroke SARS-CoV. To explore the reason of the increased transmissibility of SARS-CoV-2 compared with SARS-CoV, we have performed a comparative analysis on the structural proteins (spike, envelope, membrane, and nucleoprotein) of two viruses. Our analysis revealed that extensive substitutions of hydrophobic to polar and charged amino acids in spike glycoproteins of SARS-CoV2 creates an intrinsically disordered region (IDR) at the beginning of membrane-fusion subunit and intrinsically disordered residues in fusion peptide. IDR provides a potential site for proteolysis by furin and enriched disordered residues facilitate prompt fusion of the SARS-CoV2 with host membrane by recruiting molecular recognition features. Here, we have hypothesized that mutation-driven accumulation of intrinsically disordered residues in spike glycoproteins play dual role in enhancing viral transmissibility than previous SARS-coronavirus. These analyses may help in epidemic surveillance and preventive measures against COVID-19. |*Disease Outbreaks[MESH] |Amino Acid Sequence[MESH] |COVID-19/*epidemiology/transmission/virology[MESH] |Humans[MESH] |Membrane Fusion/*genetics[MESH] |Mutation[MESH] |Protein Subunits[MESH] |SARS-CoV-2/*genetics/metabolism[MESH] |Severe acute respiratory syndrome-related coronavirus/genetics[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*genetics/metabolism[MESH] |Viral Structural Proteins/chemistry/genetics/metabolism[MESH]Mutations in membrane-fusion subunit of spike glycoprotein play crucia(epmc).pdf DeepDyve Pubget Overpricing