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10.1016/j.apsb.2020.01.007 http://scihub22266oqcxt.onion/10.1016/j.apsb.2020.01.007 33088682!7563021!33088682     free     free     free       Acta+Pharm+Sin+B 2020 ; 10 (9): 1601-1618 Nephropedia Template TP {{tp|p=33088682|t=2020. Targeting necroptosis in anticancer therapy: mechanisms and modulators |pdf=|usr=}}{{33088682}} gab.com Text Targeting necroptosis in anticancer therapy: mechanisms and modulators JO: Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=33088682 #FOAvip Necroptosis, a genetically programmed form of necrotic cell death, serves as an important pathway in human diseases. As a critical cell-killing mechanism, necroptosis is associated with cancer progression, metastasis, and immunosurveillance. Targeting necroptosis pathway by small molecule modulators is emerging as an effective approach in cancer therapy, which has the advantage to bypass the apoptosis-resistance and maintain antitumor immunity. Therefore, a better understanding of the mechanism of necroptosis and necroptosis modulators is necessary to develop novel strategies for cancer therapy. This review will summarize recent progress of the mechanisms and detecting methods of necroptosis. In particular, the relationship between necroptosis and cancer therapy and medicinal chemistry of necroptosis modulators will be focused on. Twit Text FOAVip Targeting necroptosis in anticancer therapy: mechanisms and modulators ????Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=33088682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33088682 #FOAvip English Wikipedia <ref>{{Cite pmid|33088682}}</ref> Targeting necroptosis in anticancer therapy: mechanisms and modulators #MMPMID33088682 Wu Y; Dong G; Sheng C Acta Pharm Sin B 2020[Sep]; 10 (9): 1601-1618 PMID33088682show ga Necroptosis, a genetically programmed form of necrotic cell death, serves as an important pathway in human diseases. As a critical cell-killing mechanism, necroptosis is associated with cancer progression, metastasis, and immunosurveillance. Targeting necroptosis pathway by small molecule modulators is emerging as an effective approach in cancer therapy, which has the advantage to bypass the apoptosis-resistance and maintain antitumor immunity. Therefore, a better understanding of the mechanism of necroptosis and necroptosis modulators is necessary to develop novel strategies for cancer therapy. This review will summarize recent progress of the mechanisms and detecting methods of necroptosis. In particular, the relationship between necroptosis and cancer therapy and medicinal chemistry of necroptosis modulators will be focused on. ?Targeting necroptosis in anticancer therapy: mechanisms and modulators(epmc).pdf DeepDyve Pubget Overpricing